Influence of Gut Flora on Diabetes Management After Kidney Transplantation

Overview

Journal BMC Nephrol

Publisher Biomed Central

Specialty Nephrology

Date 2024 Dec 23

PMID 39716100

Authors

Luo-Bei Chen

Qian Chen

Sheng Chao

Zhi-Hui Yuan

Lei Jia

Yu-Lin Niu

Affiliations

Soon will be listed here.

Abstract

Post-transplant diabetes mellitus (PTDM) is a common complication following renal transplantation, and its incidence has been gradually increasing in recent years, posing a significant public health challenge. Managing PTDM is complex, as studies suggest that it involves changes in the microbial flora across multiple organs. Recent research highlights the critical role of gut flora metabolism in the development of diabetes among post-renal transplant patients. This paper reviews the alterations in gut flora observed in PTDM patients and explores how gut flora influences PTDM. These findings may offer new perspectives on targeting gut flora metabolites for the prevention and treatment of PTDM.

References

Sinha S, Haileselassie Y, Nguyen L, Tropini C, Wang M, Becker L . Dysbiosis-Induced Secondary Bile Acid Deficiency Promotes Intestinal Inflammation. Cell Host Microbe. 2020; 27(4):659-670.e5. PMC: 8172352. DOI: 10.1016/j.chom.2020.01.021. View

Hecking M, Sharif A, Eller K, Jenssen T . Management of post-transplant diabetes: immunosuppression, early prevention, and novel antidiabetics. Transpl Int. 2020; 34(1):27-48. PMC: 7839745. DOI: 10.1111/tri.13783. View

Nickerson P . Rationale for the IMAGINE study for chronic active antibody-mediated rejection (caAMR) in kidney transplantation. Am J Transplant. 2022; 22 Suppl 4:38-44. DOI: 10.1111/ajt.17210. View

Lemoine C, Pozo M, Superina R . Overview of pediatric kidney transplantation. Semin Pediatr Surg. 2022; 31(3):151194. DOI: 10.1016/j.sempedsurg.2022.151194. View

Alegre M . Can Diet Induce Transplantation Tolerance?. J Am Soc Nephrol. 2020; 31(7):1417-1418. PMC: 7351008. DOI: 10.1681/ASN.2020050661. View

Hu D, Liu W, Yu W, Huang L, Ji C, Liu X . Psyllium seed husk regulates the gut microbiota and improves mucosal barrier injury in the colon to attenuate renal injury in 5/6 nephrectomy rats. Ren Fail. 2023; 45(1):2197076. PMC: 10078125. DOI: 10.1080/0886022X.2023.2197076. View

Oste M, Flores-Guerrero J, Gruppen E, Kieneker L, Connelly M, Otvos J . High Plasma Branched-Chain Amino Acids Are Associated with Higher Risk of Post-Transplant Diabetes Mellitus in Renal Transplant Recipients. J Clin Med. 2020; 9(2). PMC: 7073569. DOI: 10.3390/jcm9020511. View

Wang W, Xu S, Ren Z, Jiang J, Zheng S . Gut microbiota and allogeneic transplantation. J Transl Med. 2015; 13:275. PMC: 4546814. DOI: 10.1186/s12967-015-0640-8. View

Martino C, Dilmore A, Burcham Z, Metcalf J, Jeste D, Knight R . Microbiota succession throughout life from the cradle to the grave. Nat Rev Microbiol. 2022; 20(12):707-720. DOI: 10.1038/s41579-022-00768-z. View

10.

Wang K, Liao M, Zhou N, Bao L, Ma K, Zheng Z . Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids. Cell Rep. 2019; 26(1):222-235.e5. DOI: 10.1016/j.celrep.2018.12.028. View

11.

Rinninella E, Tohumcu E, Raoul P, Fiorani M, Cintoni M, Mele M . The role of diet in shaping human gut microbiota. Best Pract Res Clin Gastroenterol. 2023; 62-63:101828. DOI: 10.1016/j.bpg.2023.101828. View

12.

Mareckova O, SKALA I, Marecek Z, Maly J, KOCANDRLE V, Schuck O . Bile composition in patients with chronic renal insufficiency. Nephrol Dial Transplant. 1990; 5(6):423-5. DOI: 10.1093/ndt/5.6.423. View

13.

Hajiagha M, Taghizadeh S, Asgharzadeh M, Dao S, Ganbarov K, Kose S . Gut Microbiota and Human Body Interactions; Its Impact on Health: A Review. Curr Pharm Biotechnol. 2021; 23(1):4-14. DOI: 10.2174/1389201022666210104115836. View

14.

Mayorga-Ramos A, Barba-Ostria C, Simancas-Racines D, Guaman L . Protective role of butyrate in obesity and diabetes: New insights. Front Nutr. 2022; 9:1067647. PMC: 9730524. DOI: 10.3389/fnut.2022.1067647. View

15.

Cuna A, Morowitz M, Ahmed I, Umar S, Sampath V . Dynamics of the preterm gut microbiome in health and disease. Am J Physiol Gastrointest Liver Physiol. 2021; 320(4):G411-G419. PMC: 8238167. DOI: 10.1152/ajpgi.00399.2020. View

16.

Cao C, Zhu H, Yao Y, Zeng R . Gut Dysbiosis and Kidney Diseases. Front Med (Lausanne). 2022; 9:829349. PMC: 8927813. DOI: 10.3389/fmed.2022.829349. View

17.

Ruigrok R, Weersma R, Vich Vila A . The emerging role of the small intestinal microbiota in human health and disease. Gut Microbes. 2023; 15(1):2201155. PMC: 10120449. DOI: 10.1080/19490976.2023.2201155. View

18.

Malyszko J, Basak G, Batko K, Capasso G, Capasso A, Drozd-Sokolowska J . Haematological disorders following kidney transplantation. Nephrol Dial Transplant. 2020; 37(3):409-420. DOI: 10.1093/ndt/gfaa219. View

19.

Conte C, Secchi A . Post-transplantation diabetes in kidney transplant recipients: an update on management and prevention. Acta Diabetol. 2018; 55(8):763-779. DOI: 10.1007/s00592-018-1137-8. View

20.

Jenssen T, Hartmann A . Post-transplant diabetes mellitus in patients with solid organ transplants. Nat Rev Endocrinol. 2019; 15(3):172-188. DOI: 10.1038/s41574-018-0137-7. View