Natural Killer Cell Activity in Asthma

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1985 Jan 1

PMID 3971600

Citations 17

Authors

T Timonen

Affiliations

Soon will be listed here.

Abstract

Peripheral blood natural killer (NK) activity was analysed from 32 asthma patients and 13 control donors. Male patients and female patients with atopic asthma had significantly stronger NK activity against the leukaemic cell line K-562. Fractionation of patient mononuclear cells by discontinuous density gradient centrifugation suggested that large granular lymphocytes (LGL) were the main mediators of the NK activity in asthmatics. Based on the lytic unit calculations, the strong NK activity in asthmatics is mainly due to increased frequency of LGL in peripheral blood rather than activity of individual NK cells.

Citing Articles

Allergen-induced activation of natural killer cells represents an early-life immune response in the development of allergic asthma.

Altman M, Whalen E, Togias A, OConnor G, Bacharier L, Bloomberg G J Allergy Clin Immunol. 2018; 142(6):1856-1866.

PMID: 29518416 PMC: 6123299. DOI: 10.1016/j.jaci.2018.02.019.

Asthma and the Risk of Rheumatoid Arthritis: An Insight into the Heterogeneity and Phenotypes of Asthma.

Rolfes M, Juhn Y, Wi C, Sheen Y Tuberc Respir Dis (Seoul). 2017; 80(2):113-135.

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Natural killer cells in asthma.

Gorska M Curr Opin Allergy Clin Immunol. 2016; 17(1):50-54.

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Natural Killer Receptor 1 Dampens the Development of Allergic Eosinophilic Airway Inflammation.

Elhaik Goldman S, Moshkovits I, Shemesh A, Filiba A, Tsirulsky Y, Vronov E PLoS One. 2016; 11(8):e0160779.

PMID: 27580126 PMC: 5007051. DOI: 10.1371/journal.pone.0160779.

Natural killer cells in the development of asthma.

Mathias C Curr Allergy Asthma Rep. 2014; 15(2):500.

PMID: 25504264 DOI: 10.1007/s11882-014-0500-2.

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