SARS-CoV-2 Spike S1 Subunit Triggers Pericyte and Microvascular Dysfunction in Human Pancreatic Islets

Overview

Journal Diabetes

Specialty Endocrinology

Date 2024 Dec 23

PMID 39715591

Authors

Catarina Andrade Barboza

Luciana Mateus Goncalves

Elizabeth Pereira

Roxana Diaz Cruz

Ruy Andrade Louzada

Ruy Louzada

Maria Boulina

Joana Almaca

Affiliations

Soon will be listed here.

Abstract

Article Highlights: Different components of the renin-angiotensin system are expressed by vascular cells in human pancreatic islets. The islet microvasculature is responsive to vasoactive angiotensin peptides. This pancreatic renin-angiotensin system is targeted upon incubation with a SARS-CoV-2 spike recombinant protein. SARS-CoV-2 spike activates pericytes and constricts capillaries in human islets. Islet vascular dysfunction could contribute to dysglycemia in some patients with COVID-19.

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