Refractory Tophaceous Gout With Psoriatic Arthritis: A Case Report
Overview
Overview
Authors
Affiliations
Affiliations
Soon will be listed here.
Abstract
Although gout is a common intermittent crystalline arthropathy, tophaceous gout is a rare condition. Flares of this disease are usually treated with anti-inflammatory drugs followed by control of serum uric acid levels. We present a refractory, severe, tophaceous gout overlapping with psoriatic arthritis, presenting with a hyper-inflamed phenotype resistant to conventional anti-inflammatory and hypouricemic agents. Control of the disease was only achieved after the introduction of IL-1-blocking therapy. This case highlights the need to control inflammation as the first step in gout treatment and underscores the increasing need for personalized therapies in more complex patients.
References
1.
Low Q, Lim T, Hon S, Low Q, Wei M, Cheo S
. Management of gout in the primary care setting. Malays Fam Physician. 2022; 17(1):2-9.
PMC: 9004428.
DOI: 10.51866/rv1165.
View
2.
Felten R, Duret P, Gottenberg J, Spielmann L, Messer L
. At the crossroads of gout and psoriatic arthritis: "psout". Clin Rheumatol. 2020; 39(5):1405-1413.
DOI: 10.1007/s10067-020-04981-0.
View
3.
Giovannini I, Zabotti A, Ciccio C, Salgarello M, Cereser L, De Vita S
. Axial Psoriatic Disease: Clinical and Imaging Assessment of an Underdiagnosed Condition. J Clin Med. 2021; 10(13).
PMC: 8268702.
DOI: 10.3390/jcm10132845.
View
4.
Han X, Yin Y, Cao Y, Chu X, Han Y, Di H
. Rheumatologists' understanding of refractory gout: a questionnaire survey in China. J Int Med Res. 2021; 49(5):3000605211016149.
PMC: 8161865.
DOI: 10.1177/03000605211016149.
View
5.
Jung N, Hellmann M, Hoheisel R, Lehmann C, Haase I, Perniok A
. An open-label pilot study of the efficacy and safety of anakinra in patients with psoriatic arthritis refractory to or intolerant of methotrexate (MTX). Clin Rheumatol. 2010; 29(10):1169-73.
DOI: 10.1007/s10067-010-1504-5.
View