Maintenance of Stem Cell Self-renewal by Sex Chromosomal Zinc-finger Transcription Factors

Overview

Journal World J Methodol

Publisher Baishideng Publishing Group

Specialty General Medicine

Date 2024 Dec 23

PMID 39712568

Authors

Katsuhiro Kita

Celine Morkos

Kathleen Nolan

Affiliations

Soon will be listed here.

Abstract

In this Editorial review, we would like to focus on a very recent discovery showing the global autosomal gene regulation by Y- and inactivated X-chromosomal transcription factors, zinc finger gene on the Y chromosome (ZFY) and zinc finger protein X-linked (ZFX). ZFX and ZFY are both zinc-finger proteins that encode general transcription factors abundant in hematopoietic and embryonic stem cells. Although both proteins are homologs, interestingly, the regulation of self-renewal by these transcriptional factors is almost exclusive to ZFX. This fact implies that there are some differential roles between ZFX and ZFY in regulating the maintenance of self-renewal activity in stem cells. Besides the maintenance of stemness, ZFX overexpression or mutations may be linked to certain cancers. Although cancers and stem cells are double-edged swords, there is no study showing the link between ZFX activity and the telomere. Thus, stemness or cancers with ZFX may be linked to other molecules, such as Oct4, Sox2, Klf4, and others. Based on very recent studies and a few lines of evidence in the past decade, it appears that the ZFX is linked to the canonical Wnt signaling, which is one possible mechanism to explain the role of ZFX in the self-renewal of stem cells.

References

Luis T, Weerkamp F, Naber B, Baert M, de Haas E, Nikolic T . Wnt3a deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation. Blood. 2008; 113(3):546-54. DOI: 10.1182/blood-2008-06-163774. View

Pallipalayam Periyasamy K, Lakshmi P, Dwibedi C, Annamalai A . A database for human Y chromosome protein data. Bioinformation. 2010; 4(5):184-6. PMC: 2859573. DOI: 10.6026/97320630004184. View

Willert K, Brown J, Danenberg E, Duncan A, Weissman I, Reya T . Wnt proteins are lipid-modified and can act as stem cell growth factors. Nature. 2003; 423(6938):448-52. DOI: 10.1038/nature01611. View

van de Wetering M, Sancho E, Verweij C, de Lau W, Oving I, Hurlstone A . The beta-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell. 2002; 111(2):241-50. DOI: 10.1016/s0092-8674(02)01014-0. View

Kochoyan M, Keutmann H, Weiss M . Alternating zinc fingers in the human male associated protein ZFY: refinement of the NMR structure of an even finger by selective deuterium labeling and implications for DNA recognition. Biochemistry. 1991; 30(29):7063-72. DOI: 10.1021/bi00243a005. View

Leitao E, Schroder C, Parenti I, Dalle C, Rastetter A, Kuhnel T . Systematic analysis and prediction of genes associated with monogenic disorders on human chromosome X. Nat Commun. 2022; 13(1):6570. PMC: 9630267. DOI: 10.1038/s41467-022-34264-y. View

Palmer M, Berta P, Sinclair A, Pym B, Goodfellow P . Comparison of human ZFY and ZFX transcripts. Proc Natl Acad Sci U S A. 1990; 87(5):1681-5. PMC: 53546. DOI: 10.1073/pnas.87.5.1681. View

Reya T, Duncan A, Ailles L, Domen J, Scherer D, Willert K . A role for Wnt signalling in self-renewal of haematopoietic stem cells. Nature. 2003; 423(6938):409-14. DOI: 10.1038/nature01593. View

Teif V, Vainshtein Y, Caudron-Herger M, Mallm J, Marth C, Hofer T . Genome-wide nucleosome positioning during embryonic stem cell development. Nat Struct Mol Biol. 2012; 19(11):1185-92. DOI: 10.1038/nsmb.2419. View

10.

Pinto D, Gregorieff A, Begthel H, Clevers H . Canonical Wnt signals are essential for homeostasis of the intestinal epithelium. Genes Dev. 2003; 17(14):1709-13. PMC: 196179. DOI: 10.1101/gad.267103. View

11.

Burley S, Roeder R . Biochemistry and structural biology of transcription factor IID (TFIID). Annu Rev Biochem. 1996; 65:769-99. DOI: 10.1146/annurev.bi.65.070196.004005. View

12.

Chen X, Xu H, Yuan P, Fang F, Huss M, Vega V . Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. Cell. 2008; 133(6):1106-17. DOI: 10.1016/j.cell.2008.04.043. View

13.

Miller J . The Wnts. Genome Biol. 2002; 3(1):REVIEWS3001. PMC: 150458. DOI: 10.1186/gb-2001-3-1-reviews3001. View

14.

Liu L, Rao J, Zou T, Xiao L, Smith A, Zhuang R . Activation of Wnt3a signaling stimulates intestinal epithelial repair by promoting c-Myc-regulated gene expression. Am J Physiol Cell Physiol. 2011; 302(1):C277-85. PMC: 3328905. DOI: 10.1152/ajpcell.00341.2011. View

15.

Zhang X, Wang Y, Lu J, Xiao L, Chen H, Li Q . A conserved ZFX/WNT3 axis modulates the growth and imatinib response of chronic myeloid leukemia stem/progenitor cells. Cell Mol Biol Lett. 2023; 28(1):83. PMC: 10589942. DOI: 10.1186/s11658-023-00496-z. View

16.

Tufail M, Wu C . Wnt3a is a promising target in colorectal cancer. Med Oncol. 2023; 40(3):86. DOI: 10.1007/s12032-023-01958-2. View

17.

Cellot S, Sauvageau G . Zfx: at the crossroads of survival and self-renewal. Cell. 2007; 129(2):239-41. DOI: 10.1016/j.cell.2007.04.002. View

18.

Hantsche M, Cramer P . Conserved RNA polymerase II initiation complex structure. Curr Opin Struct Biol. 2017; 47:17-22. DOI: 10.1016/j.sbi.2017.03.013. View

19.

Nurk S, Koren S, Rhie A, Rautiainen M, Bzikadze A, Mikheenko A . The complete sequence of a human genome. Science. 2022; 376(6588):44-53. PMC: 9186530. DOI: 10.1126/science.abj6987. View

20.

Zawel L, Reinberg D . Common themes in assembly and function of eukaryotic transcription complexes. Annu Rev Biochem. 1995; 64:533-61. DOI: 10.1146/annurev.bi.64.070195.002533. View