Dengue Infection Changes the Expressions of CD154 and CD148 in Human Platelets

Overview

Journal Virus Res

Specialty Microbiology

Date 2024 Dec 22

PMID 39710119

Authors

Sayali Vedpathak

Sonali Palkar

AkhileshChandra Mishra

Vidya A Arankalle

Shubham Shrivastava

Affiliations

Soon will be listed here.

Abstract

Platelets are essential for hemostasis and vascular integrity. Platelets recognize dengue virus through the DC-SIGN receptor. Upon pathogen recognition, platelets rapidly modulate the expression of adhesion molecules to trigger immune cell interactions and regulate the immune response. In this study, we aimed to examine the expression levels of three molecules, CD151, CD154, and CD148 on platelets in dengue patients. A significantly increased expression of CD154 and reduced expression of CD148 was observed in dengue patients compared to healthy subjects (p < 0.0001). Moreover, a strong positive correlation between CD148 and CD41/CD61 (p < 0.0001) was noted in dengue patients. In summary, we demonstrated the altered expressions of CD154 and CD148 on platelets in dengue patients that may play a crucial role in dengue pathogenesis.

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