» Articles » PMID: 39705410

The Effect of Lidocaine Infusion in Oncologic Surgery: A Bibliometric Analysis Based on CiteSpace

Overview
Specialty General Medicine
Date 2024 Dec 20
PMID 39705410
Authors
Affiliations
Soon will be listed here.
Abstract

Background: Over the past 2 decades, lidocaine's application in oncologic surgery has received significant attention. It has potential antitumor effects and acts as a chemosensitizer. The aim of this study is to analyze the process and frontiers of lidocaine application in oncologic surgery over the past 20 years.

Methods: A bibliometric analysis was performed and CiteSpace software was used to conduct metrology, co-occurrence, and cluster analysis. Articles retrieved from the Web of Science database from January 1, 2004 to May 27, 2024. Inclusion criteria comprised peer-reviewed original articles or reviews on lidocaine and cancer, excluding conference abstracts, corrigenda, repeated publications, and unrelated articles.

Results: A total of 956 articles were included in this study. Two hundred seventeen were selected for detailed analysis. The annual publication count showed an overall increasing trend, peaking in 2022. The United States emerged as the leading country in terms of publication frequency and centrality. Major research themes included lidocaine's antiproliferative effects, enhancement of chemotherapy efficacy, and various administration methods.

Conclusion: Based on the above results, we draw a conclusion that the relationship between lidocaine and cancer has garnered increasing attention, with research in this area rapidly developing. Lidocaine exhibits significant antitumor effects and potential as a chemosensitizer, enhancing the efficacy of traditional chemotherapy. These findings underscore the importance of further research to fully elucidate lidocaine's mechanisms and its potential clinical applications in oncology.

References
1.
Zhang X, Pang W, Liu H, Wang J . Lidocine potentiates the cytotoxicity of 5-fluorouracil to choriocarcinoma cells by downregulating ABC transport proteins expression. J Cell Biochem. 2019; 120(10):16533-16542. DOI: 10.1002/jcb.28913. View

2.
Xiong H, Hu Q, Jiang Q . Protective effects of lidocaine on polycystic ovary syndrome through modulating ovarian granulosa cell physiology via PI3K/AKT/mTOR pathway. Cytotechnology. 2022; 74(2):283-292. PMC: 8975917. DOI: 10.1007/s10616-022-00528-0. View

3.
Ren B, Cheng M, Liu C, Zheng H, Zhang J, Chen W . Perioperative lidocaine and dexmedetomidine intravenous infusion reduce the serum levels of NETs and biomarkers of tumor metastasis in lung cancer patients: A prospective, single-center, double-blinded, randomized clinical trial. Front Oncol. 2023; 13:1101449. PMC: 10003334. DOI: 10.3389/fonc.2023.1101449. View

4.
Song Z, Tan J . Effects of Anesthesia and Anesthetic Techniques on Metastasis of Lung Cancers: A Narrative Review. Cancer Manag Res. 2022; 14:189-204. PMC: 8763573. DOI: 10.2147/CMAR.S343772. View

5.
Chang Y, Hsu Y, Liu C, Huang S, Hu M, Cheng S . Local anesthetics induce apoptosis in human thyroid cancer cells through the mitogen-activated protein kinase pathway. PLoS One. 2014; 9(2):e89563. PMC: 3931808. DOI: 10.1371/journal.pone.0089563. View