Effect of Left-to-right, Mixed Left-to-right, and Right-to-left Shunts on Inhalational Anesthetic Induction in Children: a Computer Model

Overview

Journal Anesth Analg

Specialty Anesthesiology

Date 1985 Feb 1

PMID 3970355

Citations 4

Authors

G E Tanner

D G Angers

P G Barash

A Mulla

P L Miller

P Rothstein

Affiliations

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Abstract

We describe a seven-compartment physiologic model of inhalational anesthetic induction with circulatory shunts that was used to simulate inhalational anesthetic induction in children with congenital heart disease. Our conclusions based on this model are that left-to-right (L-R) shunting has little effect on speed of induction; right-to-left (R-L) shunting significantly slows induction of N2O and halothane anesthesia; and adding an L-R shunt to a preexisting R-L shunt will attenuate the slowing of induction caused by the R-L shunt.

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