Application Status and Prospects of Multimodal EEG-fMRI in HIV-associated Neurocognitive Disorders

HIV-associated neurocognitive disorders (HAND) are one of the common complications in people living with HIV (PLWH), which can affect their attention, working memory, and other related cognitive functions. With the widespread use of combination antiretroviral therapy (cART), the incidence of HAND has declined. However, HAND is still an important complication of HIV, which not only affects the quality of life of patients but also affects their adherence to HIV treatment. Its diagnosis mainly relies on neurocognitive tests, which have a certain degree of subjectivity, making it difficult to diagnose and classify HAND accurately, and there is an urgent need to explore more sensitive biomarkers. Multimodal brain imaging has seen a surge in recent years with simultaneous EEG-fMRI being at the forefront of cognitive multimodal neuroimaging. It is a complementary fusion technique that effectively combines the high spatial resolution of fMRI with the high temporal resolution of EEG, compensating for the shortcomings of a single technique and providing a new method for studying cognitive function. It is expected to reveal the underlying mechanisms of HAND and provide high spatiotemporal warning biomarkers of HAND, which will provide a new perspective for the early diagnosis and treatment of HAND and contribute to the improvement of patient prognosis.