Protective Effects of Quercetin Against Tongue Injury and Oxidative Stress Triggered by Irinotecan: a Histopathological, Biochemical and Molecular Study

Overview

Journal Toxicol Res (Camb)

Publisher Oxford University Press

Date 2024 Dec 20

PMID 39703341

Authors

Eman Mohamed Faruk

Fatma Ibrahim

Mahmoud M Hassan

Kamal M Kamal

Dina Allam Abdelmaksoud Hassan

Ayat Abu-Elnasr Awwad

Neama Mahmoud Taha

Mohamed Ghazy Attia Hablas

Ahmed Mohammed Zaazaa

Mai Hassan Ibrahim

Affiliations

Soon will be listed here.

Abstract

Introduction: About 80% of patients receiving chemotherapeutics suffer from side effects related to the gastrointestinal tract. Irinotecan (CPT-11) is a chemotherapeutic agent usually used in treating solid tumors. Quercetin (QRT), a bioflavonoid, is an antioxidant and scavenger reactive oxygen species scavenger.

Objective: The current study explored the possible protective effects of QRT against mucosal tongue injury caused by CPT-11.

Methods: The study included four equal groups: group 1/control, group 2/QRT, group 3/CPT-11, and group 4/CPT-11 + QRT.

Results: CPT-11-induced tongue injury in the form of non-healed ulcers, absent lingual papillae, mononuclear cells infiltration, marked deposition of collagen fibers, and overexpression of CD86 and tumor necrosis factor- α (TNF-α). The increased malondialdehyde levels, decreased superoxide dismutase and total antioxidant capacity revealed that there was an oxidative stress. Also, there was a decreased countenance of Ki-67 and Bcl-2 and an increased countenance of NF-κB. The QRT-treated group showed complete ulcer healing, with histological features almost like the control group, along with minimal collagen fiber deposition, decreased reactivity to CD86 and TNF-α and improvement of oxidative stress status and the molecular study results as well.

Conclusion: QRT possess protective properties against CPT-11-triggered tongue injury.

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