Hypothesis on the Outflow of Optic Nerve Cerebrospinal Fluid in Spaceflight Associated Neuro Ocular Syndrome

Overview

Journal NPJ Microgravity

Publisher Springer Nature

Date 2024 Dec 20

PMID 39702371

Authors

Yuwei Hu

Yuanxi Lin

Lu Cheng

Yang Xu

Jian Zhang

Zheng Zheng

Huan Wang

Min Yan

Hui Chen

Affiliations

Soon will be listed here.

Abstract

Spaceflight-associated neuro-ocular syndrome (SANS) has been well documented in astronauts. However, its pathogenesis is not fully understood. New findings indicate the impaired outflow of the optic nerve cerebrospinal fluid may participate or contribute to some changes in SANS. In this perspective, we generated a hypothesis that the outflow of cerebrospinal fluid through the optic nerve sheath may be impaired under micro-gravity and then may potentially lead to SANS-related alterations.

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