KTED: a Comprehensive Web-based Database for Transposable Elements in the Korean Genome

Overview

Journal Bioinform Adv

Publisher Oxford University Press

Specialty Biology

Date 2024 Dec 19

PMID 39697868

Authors

Jin-Ok Lee

Sejoon Lee

Dongyoon Lee

Taeyeon Hwang

Soobok Joe

Jin Ok Yang

Jibin Jeong

Jung Hun Ohn

Jee Hyun Kim

Affiliations

Soon will be listed here.

Abstract

Summary: Transposable elements (TEs), commonly referred to as "mobile elements," constitute DNA segments capable of relocating within a genome. Initially disregarded as "junk DNA" devoid of specific functionality, it has become evident that TEs have diverse influences on an organism's biology and health. The impact of these elements varies according to their location, classification, and their effects on specific genes or regulatory components. Despite their significant roles, a paucity of resources concerning TEs in population-scale genome sequencing remains. Herein, we analyze whole-genome sequencing data sourced from the Korean Genome and Epidemiology Study, encompassing 2500 Korean individuals. To facilitate convenient data access and observation, we developed a web-based database, KTED. Additionally, we scrutinized the differential distributions of TEs across five distinct common disease groups: dyslipidemia, hypertension, diabetes, thyroid disease, and cancer.

Availability And Implementation: https://snubh.shinyapps.io/KTED.

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