Association Between Choroid Plexus Volume and Cognitive Function in Community-dwelling Older Adults Without Dementia: a Population-based Cross-sectional Analysis

Overview

Journal Fluids Barriers CNS

Publisher Biomed Central

Date 2024 Dec 19

PMID 39696504

Authors

Yosuke Hidaka

Mamoru Hashimoto

Takashi Suehiro

Ryuji Fukuhara

Tomohisa Ishikawa

Naoko Tsunoda

Asuka Koyama

Kazuki Honda

Yusuke Miyagawa

Kazuhiro Yoshiura

Seiji Yuuki

Naoto Kajitani

Shuken Boku

Kazunari Ishii

Manabu Ikeda

Minoru Takebayashi

Affiliations

Soon will be listed here.

Abstract

Background: An increase in choroid plexus (CP) volume may be associated with cognitive decline in older individuals without dementia. In this study, we aimed to clarify whether CP volume can serve as an imaging marker of cognitive decline, determine how strongly CP volume is associated with cognitive decline, and explore factors associated with CP volume in older adults.

Methods: We measured CP volume, brain parenchyma, and cerebrospinal fluid (CSF) spaces associated with disproportionately enlarged subarachnoid space hydrocephalus (DESH), an imaging feature of normal-pressure hydrocephalus, in community-dwelling older adults aged ≥ 65 years without dementia.

Results: In 1,370 participants, lower Mini-Mental State Examination (MMSE) scores were significantly associated with higher CP volume, even after adjusting for DESH-related CSF space and brain parenchymal volume. CP volume was more strongly associated with MMSE scores than DESH-related CSF space and brain parenchymal volume. History of smoking, white matter hyperintensity, enlarged perivascular spaces, age, body mass index, and diabetes mellitus were also associated with increased CP volume.

Conclusions: CP volume may be a highly sensitive imaging marker of cognitive decline in community-dwelling older adults without dementia, as it is linked to cognitive decline independently of brain parenchyma and CSF volumes. Our findings emphasize the importance of investigating CP volume increase to maintain cognitive function in older individuals. Accordingly, further longitudinal studies are required.

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