Aspergillomas from Gastrointestinal Tract: a Case Report and Review of the Literature

Gastrointestinal (GI) aspergillosis is a rare and fatal complication in immunocompromised patients. We present the case of a 72-year-old patient with unexplained recurrent pancytopenia who presented with fever, constipation, abdominal distention, and jaundice. Imaging revealed a mass in the ileocecal junction, and biopsy revealed Aspergillus hyphae infiltrating the bowel wall. He had no evidence of pulmonary, sinus, or central nervous system Aspergillus infection. After 1 month of antifungal treatment with oral isavuconazole, he recovered well and was discharged. The clinical manifestations of GI aspergillosis are non-specific. This case highlights the importance of increasing the awareness regarding GI aspergillosis in high-risk patients without pulmonary involvement.