Evaluation of the Prognostic Value of Lateral MAPSE in Patients with Suspected Coronary Artery Disease

Overview

Journal Int J Cardiol Heart Vasc

Date 2024 Dec 18

PMID 39691829

Authors

Chengxi Yan

Ying Chang

FangWu

Minglei Yang

Shuangfeng Dai

Jiannan Zhang

Yuelang Zhang

Affiliations

Soon will be listed here.

Abstract

Objectives: To evaluate the prognostic value of lateral mitral annular plane systolic excursion (MAPSE) in the prediction of major adverse cardiology events (MACE) in patients with suspected coronary artery disease (CAD).

Methods: 233 consecutive patients were enrolled with suspected CAD from October 2012 to September 2013 and performed contrast-enhanced cardiac magnetic resonance (CMR) and two-dimensional echocardiogram studies no later than 72 h after admission. CMR imaging protocol included 4-chamber cine(cine-CMR), cardiovascular magnetic resonance angiography (CMRA) and late gadolinium enhancement (LGE). The primary endpoint is the time of first occurrence of a MACE The independent association between lateral MAPSE and MACE was evaluated by Kaplan-Meier analysis and multivariable Cox regression analysis. C statistic and net reclassification improvement (NRI) were used to evaluate the prognostic value of lateral MAPSE in MACE.

Results: Forty-five MACE occurred during an average follow-up of 9.2 years. Patients with lateral MAPSE＜9.885 mm experienced a significantly higher incidence of MACE than patients with lateral MAPSE ≥ 9.885 mm (＜0.001). After adjustment for established univariate predictors (age, diabetes, hypertension, hypercholesterolemia, transmural myocardial infarction), lateral MAPSE remained a significant independent predictor of MACE (HR = 1.373; = 0.020). The incorporation of lateral MAPSE into the risk model resulted in significant improvement in C statistic (increasing from 0.668 to 0.844; = 0.005). NRI improvement was 0.33 (＜0.001).

Conclusions: lateral MAPSE derived from cine-CMR is an independent predictor of MACE, and improve risk reclassification beyond traditional clinical and CMR risk factors in patients with suspected coronary disease.

References

Romano S, Judd R, Kim R, Kim H, Klem I, Heitner J . Left Ventricular Long-Axis Function Assessed with Cardiac Cine MR Imaging Is an Independent Predictor of All-Cause Mortality in Patients with Reduced Ejection Fraction: A Multicenter Study. Radiology. 2017; 286(2):452-460. PMC: 5790302. DOI: 10.1148/radiol.2017170529. View

Pencina M, DAgostino Sr R, DAgostino Jr R, Vasan R . Evaluating the added predictive ability of a new marker: from area under the ROC curve to reclassification and beyond. Stat Med. 2007; 27(2):157-72. DOI: 10.1002/sim.2929. View

Seitler S, De Zoysa Anthony S, Obianyo C, Syrris P, Patel V, Sado D . Systolic anterior motion of the anterior mitral valve leaflet begins in subclinical hypertrophic cardiomyopathy. Eur Heart J Cardiovasc Imaging. 2023; 25(1):86-94. PMC: 10735306. DOI: 10.1093/ehjci/jead186. View

Budoff M, Dowe D, Jollis J, Gitter M, Sutherland J, Halamert E . Diagnostic performance of 64-multidetector row coronary computed tomographic angiography for evaluation of coronary artery stenosis in individuals without known coronary artery disease: results from the prospective multicenter ACCURACY (Assessment.... J Am Coll Cardiol. 2008; 52(21):1724-32. DOI: 10.1016/j.jacc.2008.07.031. View

Yoon Y, Kitagawa K, Kato S, Ishida M, Nakajima H, Kurita T . Prognostic value of coronary magnetic resonance angiography for prediction of cardiac events in patients with suspected coronary artery disease. J Am Coll Cardiol. 2012; 60(22):2316-22. DOI: 10.1016/j.jacc.2012.07.060. View

Wang Y, Sun L, Li S, Wang C, Pan X, Liu Y . Normal reference values for mitral annular plane systolic excursion by motion-mode and speckle tracking echocardiography: a prospective, multicentre, population-based study. Eur Heart J Cardiovasc Imaging. 2023; 24(10):1384-1393. PMC: 10531139. DOI: 10.1093/ehjci/jead187. View

Chan J, Hanekom L, Wong C, Leano R, Cho G, Marwick T . Differentiation of subendocardial and transmural infarction using two-dimensional strain rate imaging to assess short-axis and long-axis myocardial function. J Am Coll Cardiol. 2006; 48(10):2026-33. DOI: 10.1016/j.jacc.2006.07.050. View

MacNamara J, Turlington W, Dias K, Hearon Jr C, Ivey E, Delgado V . Impaired longitudinal systolic-diastolic coupling and cardiac response to exercise in patients with hypertrophic cardiomyopathy. Echocardiography. 2024; 41(6):e15857. PMC: 11250570. DOI: 10.1111/echo.15857. View

Danad I, Szymonifka J, Twisk J, Norgaard B, Zarins C, Knaapen P . Diagnostic performance of cardiac imaging methods to diagnose ischaemia-causing coronary artery disease when directly compared with fractional flow reserve as a reference standard: a meta-analysis. Eur Heart J. 2016; 38(13):991-998. PMC: 5381594. DOI: 10.1093/eurheartj/ehw095. View

10.

Nabeta T, Inomata T, Iida Y, Ikeda Y, Iwamoto M, Ishii S . Baseline cardiac magnetic resonance imaging versus baseline endomyocardial biopsy for the prediction of left ventricular reverse remodeling and prognosis in response to therapy in patients with idiopathic dilated cardiomyopathy. Heart Vessels. 2013; 29(6):784-92. PMC: 4226927. DOI: 10.1007/s00380-013-0415-1. View

11.

Rangarajan V, Chacko S, Romano S, Jue J, Jariwala N, Chung J . Left ventricular long axis function assessed during cine-cardiovascular magnetic resonance is an independent predictor of adverse cardiac events. J Cardiovasc Magn Reson. 2016; 18(1):35. PMC: 4897936. DOI: 10.1186/s12968-016-0257-y. View

12.

Andreini D, Pontone G, Mushtaq S, Bartorelli A, Bertella E, Antonioli L . A long-term prognostic value of coronary CT angiography in suspected coronary artery disease. JACC Cardiovasc Imaging. 2012; 5(7):690-701. DOI: 10.1016/j.jcmg.2012.03.009. View

13.

Wagner A, Mahrholdt H, Holly T, Elliott M, Regenfus M, Parker M . Contrast-enhanced MRI and routine single photon emission computed tomography (SPECT) perfusion imaging for detection of subendocardial myocardial infarcts: an imaging study. Lancet. 2003; 361(9355):374-9. DOI: 10.1016/S0140-6736(03)12389-6. View

14.

Ersboll M, Valeur N, Mogensen U, Andersen M, Moller J, Velazquez E . Prediction of all-cause mortality and heart failure admissions from global left ventricular longitudinal strain in patients with acute myocardial infarction and preserved left ventricular ejection fraction. J Am Coll Cardiol. 2013; 61(23):2365-73. DOI: 10.1016/j.jacc.2013.02.061. View

15.

Grani C, Eichhorn C, Biere L, Kaneko K, Murthy V, Agarwal V . Comparison of myocardial fibrosis quantification methods by cardiovascular magnetic resonance imaging for risk stratification of patients with suspected myocarditis. J Cardiovasc Magn Reson. 2019; 21(1):14. PMC: 6393997. DOI: 10.1186/s12968-019-0520-0. View

16.

Rajiah P, Kalisz K, Broncano J, Goerne H, Collins J, Francois C . Myocardial Strain Evaluation with Cardiovascular MRI: Physics, Principles, and Clinical Applications. Radiographics. 2022; 42(4):968-990. DOI: 10.1148/rg.210174. View

17.

Sari N, Soesanto A . Right ventricular function in mitral stenosis: plays a fundamental role. J Echocardiogr. 2024; 22(4):185-192. DOI: 10.1007/s12574-024-00663-x. View

18.

Koseoglu C, Oncel C, Dagasan G, Coner A, Akkaya O . Mitral annular plane systolic excursion (MAPSE) as a predictor of atrial fibrillation development after coronary artery bypass surgery. Bratisl Lek Listy. 2024; 125(8):503-507. DOI: 10.4149/BLL_2024_78. View

19.

Scott P, Morgan J, Carroll N, Murday D, Roberts P, Peebles C . The extent of left ventricular scar quantified by late gadolinium enhancement MRI is associated with spontaneous ventricular arrhythmias in patients with coronary artery disease and implantable cardioverter-defibrillators. Circ Arrhythm Electrophysiol. 2011; 4(3):324-30. DOI: 10.1161/CIRCEP.110.959544. View

20.

Nielles-Vallespin S, Khalique Z, Ferreira P, De Silva R, Scott A, Kilner P . Assessment of Myocardial Microstructural Dynamics by In Vivo Diffusion Tensor Cardiac Magnetic Resonance. J Am Coll Cardiol. 2017; 69(6):661-676. PMC: 8672367. DOI: 10.1016/j.jacc.2016.11.051. View