Acute Phase Proteins in Canine and Feline Fetal Fluids During the Second Half of Gestation

Overview

Journal Vet Anim Sci

Specialty Veterinary Medicine

Date 2024 Dec 18

PMID 39691816

Authors

Hossein Sahraei

Asghar Mogheiseh

Fatemeh Doudmani

Nasrin Kazemipour

Saeed Nazifi

Affiliations

Soon will be listed here.

Abstract

The present study aimed to evaluate the acute phase proteins (serum amyloid A, alpha-1 acid glycoprotein, and C-reactive protein) profile in canine and feline fetal fluids during the second half of gestation. Seventeen pregnant domestic short-hair queens and 19 pregnant mixed-breed bitches were enrolled. Animals were divided into three groups according to their gestational age (30-39, 40-49, and 50-60 days). After ovariohysterectomy and sample collection, the concentration of the mentioned APPs was measured by the ELISA method. There was an increasing trend in the concentration of APPs in canine fetal fluids alongside increasing pregnancy age, but these changes were not statistically significant. Canine amniotic SAA concentration was significantly higher than allantoic. The highest concentration of SAA and CRP in the feline fetal fluids was observed at days 40-49, and the maximum concentration of AGP was observed at days 50-60. For the first time, the current study investigated the APPs profile in canine and feline fetal fluids during pregnancy. The maximum concentration of APPs was observed at the end of canine pregnancy and at days 40-49 of feline pregnancy.

References

Fresno L, Rodriguez-Gil J, Rigau T, Pastor J, Rivera Del Alamo M . Modulation of the biochemical composition of amniotic and allantoic fluids as a control mechanism of feline foetal development. Placenta. 2012; 33(6):522-7. DOI: 10.1016/j.placenta.2012.03.002. View

Naidenko S, Alekseeva G, Klyuchnikova P, Erofeeva M . Changes in Serum Amyloid A Level in Domestic Cats during Pregnancy. Dokl Biol Sci. 2023; 507(1):269-271. DOI: 10.1134/S0012496622060138. View

Cray C . Acute phase proteins in animals. Prog Mol Biol Transl Sci. 2011; 105:113-50. PMC: 7149966. DOI: 10.1016/B978-0-12-394596-9.00005-6. View

Sahraei H, Mogheiseh A, Nazifi S, Divar M, Iraji F . Canine and feline foetal fluids: Volume, hormonal and biochemical characterization during pregnancy. Vet Med Sci. 2024; 10(3):e1452. PMC: 11040235. DOI: 10.1002/vms3.1452. View

Bigliardi E, Rizzi M, Bertocchi M, Denti L, Bresciani C, Vetere A . Evaluation of Biochemical Composition of Amniotic and Allantoic Fluids at Different Stages of Pregnancy in Queens. Animals (Basel). 2022; 12(11). PMC: 9179811. DOI: 10.3390/ani12111414. View

Tal S, Sutton G, Arlt S, Bar-Gal G . Analysis of biochemical parameters in canine fetal fluids during the second half of pregnancy. Theriogenology. 2022; 189:31-41. DOI: 10.1016/j.theriogenology.2022.05.009. View

Czopowicz M, Szalus-Jordanow O, Mickiewicz M, Witkowski L, Markowska-Daniel I, Stefaniak T . Acute-phase proteins in pregnant goats: a longitudinal study. J Vet Diagn Invest. 2017; 29(6):814-819. DOI: 10.1177/1040638717714295. View

Borna S, Mirzaie F, Abdollahi A . Mid-trimester amniotic fluid C-reactive protein, ferritin and lactate dehydrogenase concentrations and subsequent risk of spontaneous preterm labour. Aust N Z J Obstet Gynaecol. 2009; 49(4):400-3. DOI: 10.1111/j.1479-828X.2009.01019.x. View

Rajabi A, Mogheiseh A, Nazifi S, Ahrari-Khafi M, Dehghanian A, Vesal N . Effect of direct therapeutic ultrasound exposure of ovaries on histopathology, inflammatory response, and oxidative stress in dogs. BMC Vet Res. 2023; 19(1):88. PMC: 10360222. DOI: 10.1186/s12917-023-03657-6. View

10.

Vannucchi C, Mirandola R, Oliveira C . Acute-phase protein profile during gestation and diestrous: proposal for an early pregnancy test in bitches. Anim Reprod Sci. 2002; 74(1-2):87-99. DOI: 10.1016/s0378-4320(02)00160-4. View

11.

Eckersall P, Bell R . Acute phase proteins: Biomarkers of infection and inflammation in veterinary medicine. Vet J. 2010; 185(1):23-7. DOI: 10.1016/j.tvjl.2010.04.009. View

12.

Ceron J, Eckersall P, Martynez-Subiela S . Acute phase proteins in dogs and cats: current knowledge and future perspectives. Vet Clin Pathol. 2005; 34(2):85-99. DOI: 10.1111/j.1939-165x.2005.tb00019.x. View

13.

Veronesi M, Bolis B, Faustini M, Rota A, Mollo A . Biochemical composition of fetal fluids in at term, normal developed, healthy, viable dogs and preliminary data from pathologic littermates. Theriogenology. 2017; 108:277-283. DOI: 10.1016/j.theriogenology.2017.12.029. View

14.

Salavati S, Mogheiseh A, Nazifi S, Amiri A, Nikahval B . The effects of melatonin on the concentrations of inflammatory cytokines and proteins, serotonin, cortisol and melatonin in ovariohysterectomised female dogs. Vet Med Sci. 2023; 9(3):1103-1113. PMC: 10188054. DOI: 10.1002/vms3.1112. View

15.

Kuribayashi T, Shimada T, Matsumoto M, Kawato K, Honjyo T, Fukuyama M . Determination of serum C-reactive protein (CRP) in healthy beagle dogs of various ages and pregnant beagle dogs. Exp Anim. 2003; 52(5):387-90. DOI: 10.1538/expanim.52.387. View

16.

Musilova I, Andrys C, Krejsek J, Drahosova M, Zednikova B, Pliskova L . Amniotic fluid pentraxins: Potential early markers for identifying intra-amniotic inflammatory complications in preterm pre-labor rupture of membranes. Am J Reprod Immunol. 2017; 79(5):e12789. DOI: 10.1111/aji.12789. View

17.

Baumann H, Gauldie J . The acute phase response. Immunol Today. 1994; 15(2):74-80. DOI: 10.1016/0167-5699(94)90137-6. View

18.

Ulutas P, Musal B, Kiral F, Bildik A . Acute phase protein levels in pregnancy and oestrus cycle in bitches. Res Vet Sci. 2008; 86(3):373-6. DOI: 10.1016/j.rvsc.2008.09.001. View