Substituting Time Spent in Physical Activity and Sedentary Time and Its Association with Cardiovascular Disease Among Northwest Chinese Adults

Overview

Journal Prev Med Rep

Date 2024 Dec 18

PMID 39691358

Authors

Yutong Wang

Peiying Yang

Huimeng Liu

Suixia Cao

Jingchun Liu

Yating Huo

Kun Xu

Binyan Zhang

Mengchun Wang

Qian Huang

Chunlai Yang

Lingxia Zeng

Shaonong Dang

Baibing Mi

Affiliations

Soon will be listed here.

Abstract

Objectives: To examine the association between physical activity (PA) and leisure-time sedentary time and cardiovascular disease (CVD).

Methods: This cross-sectional study used baseline data from the Regional Ethnic Cohort Study in Northwest China from June 2018 to May 2019. PA and leisure-time sedentary time were self-reported. Logistic regression models analyzed the association of PA and leisure-time sedentary time with CVD prevalence individually and jointly. Restricted cubic spline analyses assessed dose-response relationships. Isotemporal substitution models were used to investigate substituting leisure-time sedentary time, light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA) with CVD prevalence.

Results: The prevalence of CVD was 31.8 %. Compared to the lowest quartile, participants in the highest quartile of total PA had a 32 % lower CVD prevalence (odds ratio [OR]: 0.68, 95 % confidence interval [CI]: 0.62-0.74; for trend <0.001). The fully adjusted OR for the highest quartile of leisure-time sedentary time compared to the lowest quartile was 1.09 (1.01-1.18; for trend =0.04). An L-shaped dose-response relationship was observed between PA and CVD prevalence. An active lifestyle and reduced daily leisure-time sedentary time were associated with a 26 % (0.74 [0.63-0.86]) lower CVD prevalence. Additionally, substituting 30 min/day of leisure-time sedentary time with equivalent MVPA was associated with a 2 % (0.98 [0.97-0.99]) reduction in CVD prevalence. Substituting sedentary time with LPA was associated with a lower CVD prevalence in females.

Conclusions: An active lifestyle was associated with a lower prevalence of CVD in regional populations, suggesting a feasible strategy for CVD prevention and regional health promotion.

References

Li X, Wu C, Lu J, Chen B, Li Y, Yang Y . Cardiovascular risk factors in China: a nationwide population-based cohort study. Lancet Public Health. 2020; 5(12):e672-e681. DOI: 10.1016/S2468-2667(20)30191-2. View

Li L, Dai F, Zhang D . The effect of exercise intensity types on the self-rated health status of young-old comorbidities patients: a cross-sectional study in Guangdong, China. Front Public Health. 2023; 11:1292712. PMC: 10693424. DOI: 10.3389/fpubh.2023.1292712. View

Chen X, Jiang Y, Wang L, Li Y, Zhang M, Hu N . [Leisure-time physical activity and sedentary behaviors among Chinese adults in 2010]. Zhonghua Yu Fang Yi Xue Za Zhi. 2012; 46(5):399-403. View

Eijsvogels T, Thompson P, Franklin B . The "Extreme Exercise Hypothesis": Recent Findings and Cardiovascular Health Implications. Curr Treat Options Cardiovasc Med. 2018; 20(10):84. PMC: 6132728. DOI: 10.1007/s11936-018-0674-3. View

Wang Z, Ma L, Liu M, Fan J, Hu S . Summary of the 2022 Report on Cardiovascular Health and Diseases in China. Chin Med J (Engl). 2023; 136(24):2899-2908. PMC: 10752444. DOI: 10.1097/CM9.0000000000002927. View

Janssen I, Clarke A, Carson V, Chaput J, Giangregorio L, Kho M . A systematic review of compositional data analysis studies examining associations between sleep, sedentary behaviour, and physical activity with health outcomes in adults. Appl Physiol Nutr Metab. 2020; 45(10 (Suppl. 2)):S248-S257. DOI: 10.1139/apnm-2020-0160. View

Du H, Bennett D, Li L, Whitlock G, Guo Y, Collins R . Physical activity and sedentary leisure time and their associations with BMI, waist circumference, and percentage body fat in 0.5 million adults: the China Kadoorie Biobank study. Am J Clin Nutr. 2013; 97(3):487-96. PMC: 4345799. DOI: 10.3945/ajcn.112.046854. View

Aunger J, Wagnild J . Objective and subjective measurement of sedentary behavior in human adults: A toolkit. Am J Hum Biol. 2020; 34(1):e23546. PMC: 9286366. DOI: 10.1002/ajhb.23546. View

Wang X, Ma H, Li X, Heianza Y, Manson J, Franco O . Association of Cardiovascular Health With Life Expectancy Free of Cardiovascular Disease, Diabetes, Cancer, and Dementia in UK Adults. JAMA Intern Med. 2023; 183(4):340-349. PMC: 9972243. DOI: 10.1001/jamainternmed.2023.0015. View

10.

Bennett D, Du H, Clarke R, Guo Y, Yang L, Bian Z . Association of Physical Activity With Risk of Major Cardiovascular Diseases in Chinese Men and Women. JAMA Cardiol. 2017; 2(12):1349-1358. PMC: 5814992. DOI: 10.1001/jamacardio.2017.4069. View

11.

Li J, Zhang X, Zhang M, Wang L, Yin P, Li C . Urban-rural differences in the association between occupational physical activity and mortality in Chinese working population: evidence from a nationwide cohort study. Lancet Reg Health West Pac. 2024; 46:101083. PMC: 11091516. DOI: 10.1016/j.lanwpc.2024.101083. View

12.

Huang B, Duncan M, Cistulli P, Nassar N, Hamer M, Stamatakis E . Sleep and physical activity in relation to all-cause, cardiovascular disease and cancer mortality risk. Br J Sports Med. 2021; 56(13):718-724. DOI: 10.1136/bjsports-2021-104046. View

13.

Sattelmair J, Pertman J, Ding E, Kohl 3rd H, Haskell W, Lee I . Dose response between physical activity and risk of coronary heart disease: a meta-analysis. Circulation. 2011; 124(7):789-95. PMC: 3158733. DOI: 10.1161/CIRCULATIONAHA.110.010710. View

14.

Zhu N, Zhou M, Yu C, Guo Y, Bian Z, Tan Y . [Prevalence of 'healthy lifestyle' in Chinese adults]. Zhonghua Liu Xing Bing Xue Za Zhi. 2019; 40(2):136-141. DOI: 10.3760/cma.j.issn.0254-6450.2019.02.003. View

15.

Lavie C, Ozemek C, Carbone S, Katzmarzyk P, Blair S . Sedentary Behavior, Exercise, and Cardiovascular Health. Circ Res. 2019; 124(5):799-815. DOI: 10.1161/CIRCRESAHA.118.312669. View

16.

Zhou B . Predictive values of body mass index and waist circumference for risk factors of certain related diseases in Chinese adults--study on optimal cut-off points of body mass index and waist circumference in Chinese adults. Biomed Environ Sci. 2002; 15(1):83-96. View

17.

Cao Z, Xu C, Zhang P, Wang Y . Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model. EClinicalMedicine. 2022; 48:101424. PMC: 9065298. DOI: 10.1016/j.eclinm.2022.101424. View

18.

Dumith S, Hallal P, Reis R, Kohl 3rd H . Worldwide prevalence of physical inactivity and its association with human development index in 76 countries. Prev Med. 2011; 53(1-2):24-8. DOI: 10.1016/j.ypmed.2011.02.017. View

19.

Ainsworth B, Haskell W, Herrmann S, Meckes N, Bassett Jr D, Tudor-Locke C . 2011 Compendium of Physical Activities: a second update of codes and MET values. Med Sci Sports Exerc. 2011; 43(8):1575-81. DOI: 10.1249/MSS.0b013e31821ece12. View

20.

Zhu W, Chi A, Sun Y . Physical activity among older Chinese adults living in urban and rural areas: A review. J Sport Health Sci. 2018; 5(3):281-286. PMC: 6188614. DOI: 10.1016/j.jshs.2016.07.004. View