The Power of Creatine Plus Resistance Training for Healthy Aging: Enhancing Physical Vitality and Cognitive Function

Overview

Journal Front Physiol

Date 2024 Dec 18

PMID 39691097

Authors

Diego A Bonilla

Jeffrey R Stout

Darren G Candow

Jose Daniel Jimenez-Garcia

Luis M Gomez-Miranda

Melinna Ortiz-Ortiz

Scott C Forbes

Sergej M Ostojic

Salvador Vargas-Molina

Richard B Kreider

Affiliations

Soon will be listed here.

References

Kreider R, Jager R, Purpura M . Bioavailability, Efficacy, Safety, and Regulatory Status of Creatine and Related Compounds: A Critical Review. Nutrients. 2022; 14(5). PMC: 8912867. DOI: 10.3390/nu14051035. View

Candow D, Forbes S, Kirk B, Duque G . Current Evidence and Possible Future Applications of Creatine Supplementation for Older Adults. Nutrients. 2021; 13(3). PMC: 7996960. DOI: 10.3390/nu13030745. View

Yu H, Sun C, Sun B, Chen X, Tan Z . Systematic Review and Meta-Analysis of the Relationship between Actual Exercise Intensity and Rating of Perceived Exertion in the Overweight and Obese Population. Int J Environ Res Public Health. 2021; 18(24). PMC: 8701059. DOI: 10.3390/ijerph182412912. View

McKeon G, Papadopoulos E, Firth J, Joshi R, Teasdale S, Newby J . Social media interventions targeting exercise and diet behaviours in people with noncommunicable diseases (NCDs): A systematic review. Internet Interv. 2022; 27:100497. PMC: 8841579. DOI: 10.1016/j.invent.2022.100497. View

Delpino F, Figueiredo L, Forbes S, Candow D, Santos H . Influence of age, sex, and type of exercise on the efficacy of creatine supplementation on lean body mass: A systematic review and meta-analysis of randomized clinical trials. Nutrition. 2022; 103-104:111791. DOI: 10.1016/j.nut.2022.111791. View

Candow D, Forbes S, Chilibeck P, Cornish S, Antonio J, Kreider R . Effectiveness of Creatine Supplementation on Aging Muscle and Bone: Focus on Falls Prevention and Inflammation. J Clin Med. 2019; 8(4). PMC: 6518405. DOI: 10.3390/jcm8040488. View

Ostojic S, Korovljev D, Stajer V . Dietary intake of creatine and risk of medical conditions in U.S. older men and women: Data from the 2017-2018 National Health and Nutrition Examination Survey. Food Sci Nutr. 2021; 9(10):5746-5754. PMC: 8498075. DOI: 10.1002/fsn3.2543. View

Ostojic S, Grasaas E, Baltic S, Cvejic J . Dietary creatine is associated with lower serum neurofilament light chain levels. Appl Physiol Nutr Metab. 2024; 49(8):1121-1123. DOI: 10.1139/apnm-2024-0064. View

Moore D . Keeping older muscle “young” through dietary protein and physical activity. Adv Nutr. 2014; 5(5):599S-607S. PMC: 4188243. DOI: 10.3945/an.113.005405. View

10.

Candow D, Moriarty T . Effects of Creatine Monohydrate Supplementation on Muscle, Bone and Brain- Hope or Hype for Older Adults?. Curr Osteoporos Rep. 2024; 23(1):1. DOI: 10.1007/s11914-024-00895-x. View

11.

Balestrino M . Role of Creatine in the Heart: Health and Disease. Nutrients. 2021; 13(4). PMC: 8067763. DOI: 10.3390/nu13041215. View

12.

Desveaux L, Beauchamp M, Goldstein R, Brooks D . Community-based exercise programs as a strategy to optimize function in chronic disease: a systematic review. Med Care. 2013; 52(3):216-26. DOI: 10.1097/MLR.0000000000000065. View

13.

Harris R, Soderlund K, Hultman E . Elevation of creatine in resting and exercised muscle of normal subjects by creatine supplementation. Clin Sci (Lond). 1992; 83(3):367-74. DOI: 10.1042/cs0830367. View

14.

Bonilla D, Kreider R, Stout J, Forero D, Kerksick C, Roberts M . Metabolic Basis of Creatine in Health and Disease: A Bioinformatics-Assisted Review. Nutrients. 2021; 13(4). PMC: 8070484. DOI: 10.3390/nu13041238. View

15.

Bian X, Zhu J, Jia X, Liang W, Yu S, Li Z . Suggestion of creatine as a new neurotransmitter by approaches ranging from chemical analysis and biochemistry to electrophysiology. Elife. 2023; 12. PMC: 10735228. DOI: 10.7554/eLife.89317. View

16.

Bonilla D, Moreno Y, Rawson E, Forero D, Stout J, Kerksick C . A Convergent Functional Genomics Analysis to Identify Biological Regulators Mediating Effects of Creatine Supplementation. Nutrients. 2021; 13(8). PMC: 8397972. DOI: 10.3390/nu13082521. View

17.

Ostojic S . Dietary creatine intake in U.S. population: NHANES 2017-2018. Nutrition. 2021; 87-88:111207. DOI: 10.1016/j.nut.2021.111207. View

18.

Izquierdo M, Merchant R, Morley J, Anker S, Aprahamian I, Arai H . International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines. J Nutr Health Aging. 2021; 25(7):824-853. DOI: 10.1007/s12603-021-1665-8. View

19.

Magrans-Courtney T, Wilborn C, Rasmussen C, Ferreira M, Greenwood L, Campbell B . Effects of diet type and supplementation of glucosamine, chondroitin, and MSM on body composition, functional status, and markers of health in women with knee osteoarthritis initiating a resistance-based exercise and weight loss program. J Int Soc Sports Nutr. 2011; 8(1):8. PMC: 3141631. DOI: 10.1186/1550-2783-8-8. View

20.

. Collection and review of updated scientific epidemiological data on porcine epidemic diarrhoea. EFSA J. 2020; 14(2):4375. PMC: 7163754. DOI: 10.2903/j.efsa.2016.4375. View