The Function of MiRNAs in the Immune System's Inflammatory Reaction to Heart Failure

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2024 Dec 17

PMID 39687084

Authors

Kadierya Yibulayin

Maidinaimu Abulizi

Affiliations

Soon will be listed here.

Abstract

Heart failure is the end stage of cardiovascular disease, with high morbidity and mortality rates worldwide. Heart failure is associated with long-term and insufficient inhibition of inflammatory response. miRNA is a class of endogenous, non-coding, single-stranded small RNA molecules, that can regulate gene expression through translational inhibition or degradation of targeted mRNA, widely regulate myocardial remodeling, inflammatory response, and other pathological processes, and play an important regulatory role in the occurrence and development of cardiovascular diseases. This article reviews the role of miRNA in the inflammatory response in heart failure.

References

Janaszak-Jasiecka A, Siekierzycka A, Ploska A, Dobrucki I, Kalinowski L . Endothelial Dysfunction Driven by Hypoxia-The Influence of Oxygen Deficiency on NO Bioavailability. Biomolecules. 2021; 11(7). PMC: 8301841. DOI: 10.3390/biom11070982. View

Di Virgilio F, Sarti A, Coutinho-Silva R . Purinergic signaling, DAMPs, and inflammation. Am J Physiol Cell Physiol. 2020; 318(5):C832-C835. DOI: 10.1152/ajpcell.00053.2020. View

Shao Y, Saredy J, Yang W, Sun Y, Lu Y, Saaoud F . Vascular Endothelial Cells and Innate Immunity. Arterioscler Thromb Vasc Biol. 2020; 40(6):e138-e152. PMC: 7263359. DOI: 10.1161/ATVBAHA.120.314330. View

Li L, Wu F, Xie Y, Xu W, Xiong G, Xu Y . MiR-202-3p Inhibits Foam Cell Formation and is Associated with Coronary Heart Disease Risk in a Chinese Population. Int Heart J. 2020; 61(1):153-159. DOI: 10.1536/ihj.19-033. View

Hill M, Tran N . miRNA interplay: mechanisms and consequences in cancer. Dis Model Mech. 2021; 14(4). PMC: 8077553. DOI: 10.1242/dmm.047662. View

Groot M, Lee H . Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases. Cells. 2020; 9(4). PMC: 7226101. DOI: 10.3390/cells9041044. View

You D, Qiao Q, Ono K, Wei M, Tan W, Wang C . miR-223-3p inhibits the progression of atherosclerosis via down-regulating the activation of MEK1/ERK1/2 in macrophages. Aging (Albany NY). 2022; 14(4):1865-1878. PMC: 8908932. DOI: 10.18632/aging.203908. View

Feng H, Xie B, Zhang Z, Yan J, Cheng M, Zhou Y . MiR-135a Protects against Myocardial Injury by Targeting TLR4. Chem Pharm Bull (Tokyo). 2021; 69(6):529-536. DOI: 10.1248/cpb.c20-01003. View

Antunes J, Benarroch L, Moraes F, Juenet M, Gross M, Aubart M . Core-Shell Polymer-Based Nanoparticles Deliver miR-155-5p to Endothelial Cells. Mol Ther Nucleic Acids. 2019; 17:210-222. PMC: 6610682. DOI: 10.1016/j.omtn.2019.05.016. View

10.

He L, Wang Z, Zhou R, Xiong W, Yang Y, Song N . Dexmedetomidine exerts cardioprotective effect through miR-146a-3p targeting IRAK1 and TRAF6 via inhibition of the NF-κB pathway. Biomed Pharmacother. 2020; 133:110993. DOI: 10.1016/j.biopha.2020.110993. View

11.

Kilikevicius A, Meister G, Corey D . Reexamining assumptions about miRNA-guided gene silencing. Nucleic Acids Res. 2021; 50(2):617-634. PMC: 8789053. DOI: 10.1093/nar/gkab1256. View

12.

Hinkel R, Ramanujam D, Kaczmarek V, Howe A, Klett K, Beck C . AntimiR-21 Prevents Myocardial Dysfunction in a Pig Model of Ischemia/Reperfusion Injury. J Am Coll Cardiol. 2020; 75(15):1788-1800. DOI: 10.1016/j.jacc.2020.02.041. View

13.

Schutte J, Manke M, Hemmen K, Munzer P, Schorg B, Ramos G . Platelet-Derived MicroRNAs Regulate Cardiac Remodeling After Myocardial Ischemia. Circ Res. 2023; 132(7):e96-e113. DOI: 10.1161/CIRCRESAHA.122.322459. View

14.

Li J, Yang C, Wang Y . miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells. Mol Med Rep. 2020; 23(2). PMC: 7789090. DOI: 10.3892/mmr.2020.11804. View

15.

Ge X, Meng Q, Wei L, Liu J, Li M, Liang X . Myocardial ischemia-reperfusion induced cardiac extracellular vesicles harbour proinflammatory features and aggravate heart injury. J Extracell Vesicles. 2021; 10(4):e12072. PMC: 7902529. DOI: 10.1002/jev2.12072. View

16.

Jayasuriya R, Ganesan K, Xu B, Ramkumar K . Emerging role of long non-coding RNAs in endothelial dysfunction and their molecular mechanisms. Biomed Pharmacother. 2021; 145:112421. DOI: 10.1016/j.biopha.2021.112421. View

17.

Silvestre-Roig C, Braster Q, Ortega-Gomez A, Soehnlein O . Neutrophils as regulators of cardiovascular inflammation. Nat Rev Cardiol. 2020; 17(6):327-340. DOI: 10.1038/s41569-019-0326-7. View

18.

Kalayinia S, Arjmand F, Maleki M, Malakootian M, Singh C . MicroRNAs: roles in cardiovascular development and disease. Cardiovasc Pathol. 2020; 50:107296. DOI: 10.1016/j.carpath.2020.107296. View

19.

Dyavanapalli J, Hora A, Escobar J, Schloen J, Dwyer M, Rodriguez J . Chemogenetic activation of intracardiac cholinergic neurons improves cardiac function in pressure overload-induced heart failure. Am J Physiol Heart Circ Physiol. 2020; 319(1):H3-H12. PMC: 7474442. DOI: 10.1152/ajpheart.00150.2020. View

20.

Dauerman H, Ibanez B . The Edge of Time in Acute Myocardial Infarction. J Am Coll Cardiol. 2021; 77(15):1871-1874. DOI: 10.1016/j.jacc.2021.03.003. View