Exploring Novel Markers for Coronary Heart Disease Associated with Systemic Lupus Erythematosus: A Review

Overview

Journal Medicine (Baltimore)

Specialty General Medicine

Date 2024 Dec 17

PMID 39686502

Authors

Linping Du

Yuqun Wang

Honglei Ma

Jiaheng Fan

Shiqi Wang

Junhong Liu

Xiaodong Wang

Affiliations

Soon will be listed here.

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune condition that is characterized by the production of autoantibodies and sustained inflammatory damage. Coronary heart disease (CHD) is a common complication of SLE, significantly increases CHD-related mortality in SLE patients. Despite conventional risk factors, the mechanisms contributing to a higher CHD risk require further investigation, with the immune and inflammatory aspects of SLE playing a significant role. Endothelial cell damage and dysfunction are key factors in the progression of coronary atherosclerosis in SLE patients. This review specifically focuses on endothelial dysfunction and the role of specific microRNAs in the context of SLE and CHD. In addition, we discuss the effects and functions of oxidative stress markers, endothelial progenitor cells, and circulating endothelial cells in individuals with both SLE and CHD. We also explored the typical inflammatory markers associated with SLE and CHD, addressing their clinical significance and limitations.

References

Xu S, Ilyas I, Little P, Li H, Kamato D, Zheng X . Endothelial Dysfunction in Atherosclerotic Cardiovascular Diseases and Beyond: From Mechanism to Pharmacotherapies. Pharmacol Rev. 2021; 73(3):924-967. DOI: 10.1124/pharmrev.120.000096. View

Medina-Leyte D, Zepeda-Garcia O, Dominguez-Perez M, Gonzalez-Garrido A, Villarreal-Molina T, Jacobo-Albavera L . Endothelial Dysfunction, Inflammation and Coronary Artery Disease: Potential Biomarkers and Promising Therapeutical Approaches. Int J Mol Sci. 2021; 22(8). PMC: 8068178. DOI: 10.3390/ijms22083850. View

Moore K, Sheedy F, Fisher E . Macrophages in atherosclerosis: a dynamic balance. Nat Rev Immunol. 2013; 13(10):709-21. PMC: 4357520. DOI: 10.1038/nri3520. View

Reiss A, Jacob B, Ahmed S, Carsons S, DeLeon J . Understanding Accelerated Atherosclerosis in Systemic Lupus Erythematosus: Toward Better Treatment and Prevention. Inflammation. 2021; 44(5):1663-1682. DOI: 10.1007/s10753-021-01455-6. View

Duan H, Zhang Q, Liu J, Li R, Wang D, Peng W . Suppression of apoptosis in vascular endothelial cell, the promising way for natural medicines to treat atherosclerosis. Pharmacol Res. 2021; 168:105599. DOI: 10.1016/j.phrs.2021.105599. View

Oliveira A, Arismendi M, Machado L, Sato E . Ramipril Improves Endothelial Function and Increases the Number of Endothelial Progenitor Cells in Patients With Systemic Lupus Erythematosus. J Clin Rheumatol. 2022; 28(7):349-353. DOI: 10.1097/RHU.0000000000001869. View

Oliveira C, Kaplan M . Cardiovascular disease risk and pathogenesis in systemic lupus erythematosus. Semin Immunopathol. 2022; 44(3):309-324. PMC: 9064999. DOI: 10.1007/s00281-022-00922-y. View

LeLeiko R, Vaccari C, Sola S, Merchant N, Nagamia S, Thoenes M . Usefulness of elevations in serum choline and free F2)-isoprostane to predict 30-day cardiovascular outcomes in patients with acute coronary syndrome. Am J Cardiol. 2009; 104(5):638-43. DOI: 10.1016/j.amjcard.2009.04.047. View

Clarke J . LDL subfraction linked to vascular ageing and heart disease in SLE. Nat Rev Rheumatol. 2020; 16(4):187. DOI: 10.1038/s41584-020-0398-0. View

10.

Asgeirsdottir S, van Solingen C, Kurniati N, Zwiers P, Heeringa P, van Meurs M . MicroRNA-126 contributes to renal microvascular heterogeneity of VCAM-1 protein expression in acute inflammation. Am J Physiol Renal Physiol. 2012; 302(12):F1630-9. DOI: 10.1152/ajprenal.00400.2011. View

11.

Sciatti E, Cavazzana I, Vizzardi E, Bonadei I, Fredi M, Taraborelli M . Systemic Lupus Erythematosus and Endothelial Dysfunction: A Close Relationship. Curr Rheumatol Rev. 2018; 15(3):177-188. DOI: 10.2174/1573397115666181126105318. View

12.

Tsai C, Li K, Shen C, Lu C, Lee H, Wu T . Decipher the Immunopathological Mechanisms and Set Up Potential Therapeutic Strategies for Patients with Lupus Nephritis. Int J Mol Sci. 2023; 24(12). PMC: 10298725. DOI: 10.3390/ijms241210066. View

13.

Wang L, Luqmani R, Udalova I . The role of neutrophils in rheumatic disease-associated vascular inflammation. Nat Rev Rheumatol. 2022; 18(3):158-170. DOI: 10.1038/s41584-021-00738-4. View

14.

Spinelli F, Barbati C, Cecarelli F, Morello F, Colasanti T, Vomero M . B lymphocyte stimulator modulates number and function of endothelial progenitor cells in systemic lupus erythematosus. Arthritis Res Ther. 2019; 21(1):245. PMC: 6868730. DOI: 10.1186/s13075-019-2015-7. View

15.

Henderson N, Sethi T . The regulation of inflammation by galectin-3. Immunol Rev. 2009; 230(1):160-71. DOI: 10.1111/j.1600-065X.2009.00794.x. View

16.

Yin H, Distler O, Shen L, Xu X, Yuan Y, Li R . Endothelial Response to Type I Interferon Contributes to Vasculopathy and Fibrosis and Predicts Disease Progression of Systemic Sclerosis. Arthritis Rheumatol. 2023; 76(1):78-91. DOI: 10.1002/art.42662. View

17.

Volpe M, Gallo G . Hypertension, coronary artery disease and myocardial ischemic syndromes. Vascul Pharmacol. 2023; 153:107230. DOI: 10.1016/j.vph.2023.107230. View

18.

Habets K, van Puijvelde G, van Duivenvoorde L, van Wanrooij E, De Vos P, Cohen Tervaert J . Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice. Cardiovasc Res. 2009; 85(3):622-30. DOI: 10.1093/cvr/cvp338. View

19.

Mak A, Yen Chan J . Endothelial function and endothelial progenitor cells in systemic lupus erythematosus. Nat Rev Rheumatol. 2022; 18(5):286-300. DOI: 10.1038/s41584-022-00770-y. View

20.

Reddy L, Shah S, Ponde C, Rajani R, Ashavaid T . Circulating miRNA-33: a potential biomarker in patients with coronary artery disease. Biomarkers. 2018; 24(1):36-42. DOI: 10.1080/1354750X.2018.1501760. View