Dickkopf 3 As a New Monitoring Tool for Kidney Function After Living Kidney Donation

Overview

Journal J Clin Med

Specialty General Medicine

Date 2024 Dec 17

PMID 39685912

Authors

Antonia Schuster

Louisa Steines

Bernhard Banas

Tobias Bergler

Affiliations

Soon will be listed here.

Abstract

Even today, a non-invasive biomarker to identify donors with enhanced risk for renal impairment is missing. Dickkopf 3 (DKK3) can cause tubulointerstitial fibrosis and is associated with rapid eGFR loss. The aim of our work was to analyze whether DKK3 can be used as a non-invasive alert marker for an increased risk of loss of kidney function in living kidney donors (LKDs). All donors who were examined between July 2022 and June 2023 ( = 117) were included. DKK3 was measured in the urine. The collected patient-related data were compared with parameters before donation. The study cohort was stratified by DKK3 values (</≥200). In the follow-up, 89 donors had a DKK3 value < 200 (group 1) and 28 donors had a DKK3 value ≥200 (group 2). During post-donation follow-up, renal function in group 1 was significantly better than that in group 2 ( = 0.01), although no difference in renal function before donation was detected ( = 0.84). Group 2 showed also a greater eGFR loss over time than group 1. LKDs with elevated DKK3 levels in the FU had impaired kidney function without evidence of increased risk factors pre-donation. DKK3 can represent a possible monitoring tool for kidney function in LKDs.

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