The Role of Fetuin-A in Tumor Cell Growth, Prognosis, and Dissemination

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2024 Dec 17

PMID 39684629

Authors

Peace Odiase

Jonathan Ma

Sruthi Ranganathan

Olugbemiga Ogunkua

Winston B Turner

Dana Marshall

Josiah Ochieng

Affiliations

Soon will be listed here.

Abstract

Fetuin-A, also known as alpha-2-Heremans-Schmid-glycoprotein (Ahsg), is a multifunctional molecule with diverse roles in biological processes such as mineralization, tumor growth, and inflammation. This review explores the involvement of Ahsg in various cancers, including liver, breast, prostate, colorectal, brain, osteosarcoma, and lung cancers. In many cancer types, Ahsg promotes tumor growth, invasion, and metastasis through various mechanisms, including cellular adhesion, spreading, chemotaxis, and modulation of cell-growth signaling pathways. Additionally, Ahsg has been implicated in the regulation of inflammatory cytokine production, making it a potential marker of inflammation in cancer. The complex interplay between Ahsg and cancer progression highlights its potential as a diagnostic biomarker and therapeutic target in various cancers. However, further research is needed to fully elucidate the mechanisms of action of Ahsg in cancer and to explore its clinical implications in cancer diagnosis, prognosis, and treatment.

References

Sindhu S, Akhter N, Shenouda S, Wilson A, Ahmad R . Plasma fetuin-A/α2-HS-glycoprotein correlates negatively with inflammatory cytokines, chemokines and activation biomarkers in individuals with type-2 diabetes. BMC Immunol. 2016; 17(1):33. PMC: 5037637. DOI: 10.1186/s12865-016-0171-y. View

Zhao P, Wei Y, Sun G, Xu L, Wang T, Tian Y . Fetuin-A alleviates neuroinflammation against traumatic brain injury-induced microglial necroptosis by regulating Nrf-2/HO-1 pathway. J Neuroinflammation. 2022; 19(1):269. PMC: 9636801. DOI: 10.1186/s12974-022-02633-5. View

Comunale M, Wang M, Hafner J, Krakover J, Rodemich L, Kopenhaver B . Identification and development of fucosylated glycoproteins as biomarkers of primary hepatocellular carcinoma. J Proteome Res. 2008; 8(2):595-602. PMC: 4427194. DOI: 10.1021/pr800752c. View

Bozycki L, Mroczek J, Bessueille L, Mebarek S, Buchet R, Pikula S . Annexins A2, A6 and Fetuin-A Affect the Process of Mineralization in Vesicles Derived from Human Osteoblastic hFOB 1.19 and Osteosarcoma Saos-2 Cells. Int J Mol Sci. 2021; 22(8). PMC: 8069967. DOI: 10.3390/ijms22083993. View

van Linde M, van der Mijn J, Pham T, Knol J, Wedekind L, Hovinga K . Evaluation of potential circulating biomarkers for prediction of response to chemoradiation in patients with glioblastoma. J Neurooncol. 2016; 129(2):221-30. PMC: 4992035. DOI: 10.1007/s11060-016-2178-x. View

Azuma K, Serada S, Takamatsu S, Terao N, Takeishi S, Kamada Y . Identification of sialylated glycoproteins in Doxorubicin-treated hepatoma cells with glycoproteomic analyses. J Proteome Res. 2014; 13(11):4869-77. DOI: 10.1021/pr5004399. View

Chatterjee P, Seal S, Mukherjee S, Kundu R, Mukherjee S, Ray S . Adipocyte fetuin-A contributes to macrophage migration into adipose tissue and polarization of macrophages. J Biol Chem. 2013; 288(39):28324-30. PMC: 3784748. DOI: 10.1074/jbc.C113.495473. View

Icer M, Yildiran H . Effects of fetuin-A with diverse functions and multiple mechanisms on human health. Clin Biochem. 2020; 88:1-10. DOI: 10.1016/j.clinbiochem.2020.11.004. View

Dalamaga M, Polyzos S, Karmaniolas K, Chamberland J, Lekka A, Migdalis I . Circulating fetuin-A in patients with pancreatic cancer: a hospital-based case-control study. Biomarkers. 2014; 19(8):660-6. DOI: 10.3109/1354750X.2014.974071. View

10.

Dowling P, ODriscoll L, Meleady P, Henry M, Roy S, Ballot J . 2-D difference gel electrophoresis of the lung squamous cell carcinoma versus normal sera demonstrates consistent alterations in the levels of ten specific proteins. Electrophoresis. 2007; 28(23):4302-10. DOI: 10.1002/elps.200700246. View

11.

Li J, Yang F, Wei F, Ren X . The role of toll-like receptor 4 in tumor microenvironment. Oncotarget. 2017; 8(39):66656-66667. PMC: 5630445. DOI: 10.18632/oncotarget.19105. View

12.

Ochieng J, Nangami G, Sakwe A, Rana T, Ingram S, Goodwin J . Extracellular histones are the ligands for the uptake of exosomes and hydroxyapatite-nanoparticles by tumor cells via syndecan-4. FEBS Lett. 2018; 592(19):3274-3285. PMC: 6188801. DOI: 10.1002/1873-3468.13236. View

13.

Kundranda M, Henderson M, Carter K, Gorden L, Binhazim A, Ray S . The serum glycoprotein fetuin-A promotes Lewis lung carcinoma tumorigenesis via adhesive-dependent and adhesive-independent mechanisms. Cancer Res. 2005; 65(2):499-506. View

14.

Ragab S, Badr E . Evaluation of serum and urine fetuin-A levels in children with acute lymphoblastic leukemia during and after high-dose methotrexate therapy: Relation to toxicity. Hematology. 2015; 21(2):78-91. DOI: 10.1179/1607845415Y.0000000042. View

15.

Ochieng J, Korolkova O, Li G, Jin R, Chen Z, Matusik R . Fetuin-A Promotes 3-Dimensional Growth in LNCaP Prostate Cancer Cells by Sequestering Extracellular Vesicles to Their Surfaces to Act as Signaling Platforms. Int J Mol Sci. 2022; 23(7). PMC: 8999611. DOI: 10.3390/ijms23074031. View

16.

Danda R, Ganapathy K, Sathe G, Madugundu A, Ramachandran S, Krishnan U . Proteomic profiling of retinoblastoma by high resolution mass spectrometry. Clin Proteomics. 2016; 13:29. PMC: 5080735. DOI: 10.1186/s12014-016-9128-7. View

17.

Wang H, Zhang M, Bianchi M, Sherry B, Sama A, Tracey K . Fetuin (alpha2-HS-glycoprotein) opsonizes cationic macrophagedeactivating molecules. Proc Natl Acad Sci U S A. 1998; 95(24):14429-34. PMC: 24390. DOI: 10.1073/pnas.95.24.14429. View

18.

He L, Shi X, Liu Z, Ren X, Zhang C, Yang Z . Roles Of EAAT1, DHFR, And Fetuin-A In The Pathogenesis, Progression And Prognosis Of Chondrosarcoma. Onco Targets Ther. 2019; 12:8411-8420. PMC: 6811368. DOI: 10.2147/OTT.S222426. View

19.

Greer E, Brunet A . FOXO transcription factors in ageing and cancer. Acta Physiol (Oxf). 2008; 192(1):19-28. DOI: 10.1111/j.1748-1716.2007.01780.x. View

20.

Nair R, Mazza D, Brambilla F, Gorzanelli A, Agresti A, Bianchi M . LPS-Challenged Macrophages Release Microvesicles Coated With Histones. Front Immunol. 2018; 9:1463. PMC: 6030250. DOI: 10.3389/fimmu.2018.01463. View