Exploring 4,7-Disubstituted Pyrimido[4,5-]pyrimidines As Antiviral and Anticancer Agents

Overview

Journal Molecules

Publisher MDPI

Specialty Biology

Date 2024 Dec 17

PMID 39683709

Authors

Eleftheria A Georgiou

Konstantinos Paraskevas

Christina Koutra

Leentje Persoons

Dominique Schols

Steven De Jonghe

Ioannis K Kostakis

Affiliations

Soon will be listed here.

Abstract

Thirteen new 4,7-disubstituted pyrimido[4,5-]pyrimidines were synthesized via a straightforward methodology starting from thiourea. The anti-proliferative activity of these compounds was evaluated across a diverse panel of eight cancer cell lines, with derivatives and showing efficacy against several hematological cancer types. Furthermore, all compounds were assessed for their antiviral potency against a panel of viruses. Compounds featuring a cyclopropylamino group and an aminoindane moiety exhibited remarkable efficacy against human coronavirus 229E (HCoV-229E). These findings highlight the pyrimidino[4,5-]pyrimidine scaffold as an interesting framework for the design of novel antiviral agents against HCoVs, with compounds , , and emerging as strong candidates for further investigation.

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