The Effects of Different Treatments on Serum Trace Element Levels in Dogs with Heart Failure

Overview

Journal Animals (Basel)

Date 2024 Dec 17

PMID 39682356

Authors

Bengu Bilgic

Duygu Tarhan

Mehmet Erman Or

Affiliations

Soon will be listed here.

Abstract

The prognostic and diagnostic role of some trace elements in heart diseases has been demonstrated. In this study, the effects of min. 30-day and min. 120-day treatment with pimobendan, enalapril, and furosemide, as monotherapy and in combination, on serum trace element levels in dogs with heart failure were evaluated. A total of 107 dogs were treated with pimobendan or enalapril as monotherapy and pimobendan + enalapril (PE), enalapril + furosemide (EF), or pimobendan + enalapril + furosemide (PEF) as combination therapy for a min. of 30 and 120 days. Serum copper (Cu), zinc (Zn), iron (Fe), cobalt (Co), magnesium (Mg), manganese (Mn), selenium (Se), and chromium (Cr) were measured by an inductive coupled plasma optical emission spectroscopy device. Mean serum Mg in dogs treated with pimobendan for a min. of 120 days was significantly lower than that for a min. of 30 days ( < 0.05). In dogs using the PEF combination, mean serum Fe was significantly higher in the min. 120-day treatment group than in the min. 30-day treatment group ( < 0.01). No significant difference was observed in mean serum Cu, Zn, Co, Mn, Se, or Cr between the treatment groups and the time periods ( > 0.05). The short- and long-term use of pimobendan, enalapril, furosemide, and their combinations may cause changes in mean serum Mg and Fe in dogs with heart failure.

References

Mohr I, Weiss K . Current anti-copper therapies in management of Wilson disease. Ann Transl Med. 2019; 7(Suppl 2):S69. PMC: 6531644. DOI: 10.21037/atm.2019.02.48. View

Elsherif L, Ortines R, Saari J, Kang Y . Congestive heart failure in copper-deficient mice. Exp Biol Med (Maywood). 2003; 228(7):811-7. DOI: 10.1177/15353702-0322807-06. View

Tong G, Rude R . Magnesium deficiency in critical illness. J Intensive Care Med. 2005; 20(1):3-17. DOI: 10.1177/0885066604271539. View

CHIPPERFIELD B, Chipperfield J . Differences in metal content of the heart muscle in death from ischemic heart disease. Am Heart J. 1978; 95(6):732-7. DOI: 10.1016/0002-8703(78)90503-3. View

Khan A, Lubitz S, Sullivan L, Sun J, Levy D, Vasan R . Low serum magnesium and the development of atrial fibrillation in the community: the Framingham Heart Study. Circulation. 2012; 127(1):33-8. PMC: 3541701. DOI: 10.1161/CIRCULATIONAHA.111.082511. View

Cummings J, Kovacic J . The ubiquitous role of zinc in health and disease. J Vet Emerg Crit Care (San Antonio). 2009; 19(3):215-40. DOI: 10.1111/j.1476-4431.2009.00418.x. View

Scott M, Olson G, Krook L, Brown W . Selenium-responsive myopathies of myocardium of smooth muscle in the young poult. J Nutr. 1967; 91(4):573-83. DOI: 10.1093/jn/91.4.573. View

Kang Y, Wu H, Saari J . Alterations in hypertrophic gene expression by dietary copper restriction in mouse heart. Proc Soc Exp Biol Med. 2000; 223(3):282-7. DOI: 10.1046/j.1525-1373.2000.22340.x. View

ONeal S, Zheng W . Manganese Toxicity Upon Overexposure: a Decade in Review. Curr Environ Health Rep. 2015; 2(3):315-28. PMC: 4545267. DOI: 10.1007/s40572-015-0056-x. View

10.

Spasov A, Ozerov A, Iezhitsa I, Kharitonova M, Kravchenko M, Zheltova A . Correction of furosemide-induced magnesium deficiency with different stereoisomers of organic magnesium salts: a comparative study. Bull Exp Biol Med. 2012; 151(3):333-5. DOI: 10.1007/s10517-011-1323-y. View

11.

Morin Y, Tetu A, Mercier G . Québec beer-drinkers' cardiomyopathy: clinical and hemodynamic aspects. Ann N Y Acad Sci. 1969; 156(1):566-76. DOI: 10.1111/j.1749-6632.1969.tb16751.x. View

12.

Zama N, Towns R . Cardiac copper, magnesium, and zinc in recent and old myocardial infarction. Biol Trace Elem Res. 2013; 10(3):201-8. DOI: 10.1007/BF02795618. View

13.

da Cunha S, Albanesi Filho F, Bastos V, Antelo D, de Souza M . Thiamin, selenium, and copper levels in patients with idiopathic dilated cardiomyopathy taking diuretics. Arq Bras Cardiol. 2002; 79(5):454-65. DOI: 10.1590/s0066-782x2002001400003. View

14.

Jiang Y, Zheng W . Cardiovascular toxicities upon manganese exposure. Cardiovasc Toxicol. 2005; 5(4):345-54. PMC: 3980854. DOI: 10.1385/ct:5:4:345. View

15.

Boyle K, Leech E . A review of the pharmacology and clinical uses of pimobendan. J Vet Emerg Crit Care (San Antonio). 2012; 22(4):398-408. DOI: 10.1111/j.1476-4431.2012.00768.x. View

16.

Young I, Goh E, McKillop U, Stanford C, Nicholls D, Trimble E . Magnesium status and digoxin toxicity. Br J Clin Pharmacol. 1991; 32(6):717-21. PMC: 1368552. View

17.

Kieboom B, Niemeijer M, Leening M, van den Berg M, Franco O, Deckers J . Serum Magnesium and the Risk of Death From Coronary Heart Disease and Sudden Cardiac Death. J Am Heart Assoc. 2016; 5(1). PMC: 4859391. DOI: 10.1161/JAHA.115.002707. View

18.

Choi S, Liu X, Pan Z . Zinc deficiency and cellular oxidative stress: prognostic implications in cardiovascular diseases. Acta Pharmacol Sin. 2018; 39(7):1120-1132. PMC: 6289396. DOI: 10.1038/aps.2018.25. View

19.

Eknoyan G, Suki W, MARTINEZ-MALDONADO M . Effect of diuretics on urinary excretion of phosphate, calcium, and magnesium in thyroparathyroidectomized dogs. J Lab Clin Med. 1970; 76(2):257-66. View

20.

Dos Santos L, de Freitas Santos Junior A, Korn M . Effects of furosemide administration on the concentration of essential and toxic elements in Wistar rats by inductively coupled plasma optical emission spectrometry. J Trace Elem Med Biol. 2018; 48:25-29. DOI: 10.1016/j.jtemb.2018.02.029. View