Associations Between Phenotypes of Childhood and Adolescent Obesity and Incident Hypertension in Young Adulthood

Overview

Journal Int J Obes (Lond)

Specialty Endocrinology

Date 2024 Dec 16

PMID 39681621

Authors

Ruth G St Fleur

Marian Tanofsky-Kraff

Jack A Yanovski

Nicholas J Horton

Laura Reich

Jorge E Chavarro

Joel N Hirschhorn

Hannah N Ziobrowski

Alison E Field

Affiliations

Soon will be listed here.

Abstract

Objectives: We investigated whether empirically derived childhood obesity phenotypes were differentially associated with risk of hypertension in young adulthood, and whether these associations differed by sex.

Methods: Data came from 11,404 participants in the Growing Up Today Study, a prospective cohort study in the US established in 1996. We used a childhood obesity phenotype variable that was previously empirically derived using latent class analysis. The childhood obesity phenotypes included an early puberty phenotype (females only), a mothers with obesity phenotype, a high weight concerns phenotype, and a mixed phenotype. Participants without overweight or obesity in childhood or adolescence were the reference group. We then used logistic regression models with generalized estimating equations to examine associations of childhood obesity phenotypes with incident hypertension between ages 20-35 years. All analyses were stratified by sex.

Results: Among females, participants in all of the empirically derived childhood obesity phenotypes were more likely than their peers without childhood overweight/obesity to develop hypertension in young adulthood (early puberty subtype odds ratio (OR) = 2.52; 95% confidence interval (CI) = 1.75, 3.62; mothers with obesity (MO) subtype OR = 2.98; 95% CI = 1.93, 4.59; high weight concerns (WC) subtype OR = 2.33; 95% CI = 1.65, 3.28; mixed subtype OR = 1.66; 95% CI = 1.25, 2.20). Among males, the childhood obesity phenotypes were associated with a higher risk of developing hypertension, although males in the MO (OR = 2.65; 95% CI = 1.82, 3.87) and WC phenotypes (OR = 3.52; 95% CI = 2.38, 5.20) had a greater risk of developing hypertension than the mixed subtype (OR = 1.51; 95% CI = 1.23, 1.86) (p = 0.004).

Conclusion: Risk for incident hypertension in young adulthood varied by childhood obesity phenotypes, as well as by biological sex. If replicated, these results may suggest that increased surveillance of specific childhood obesity phenotypes might help in targeting those at highest risk for hypertension.

References

Xie X, Atkins E, Lv J, Bennett A, Neal B, Ninomiya T . Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2015; 387(10017):435-43. DOI: 10.1016/S0140-6736(15)00805-3. View

Olsen M, Angell S, Asma S, Boutouyrie P, Burger D, Chirinos J . A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet. 2016; 388(10060):2665-2712. DOI: 10.1016/S0140-6736(16)31134-5. View

Kjeldsen S . Hypertension and cardiovascular risk: General aspects. Pharmacol Res. 2017; 129:95-99. DOI: 10.1016/j.phrs.2017.11.003. View

Kirkland E, Heincelman M, Bishu K, Schumann S, Schreiner A, Axon R . Trends in Healthcare Expenditures Among US Adults With Hypertension: National Estimates, 2003-2014. J Am Heart Assoc. 2018; 7(11). PMC: 6015342. DOI: 10.1161/JAHA.118.008731. View

De Venecia T, Lu M, Figueredo V . Hypertension in young adults. Postgrad Med. 2016; 128(2):201-7. DOI: 10.1080/00325481.2016.1147927. View

Go A, Mozaffarian D, Roger V, Benjamin E, Berry J, Blaha M . Heart disease and stroke statistics--2014 update: a report from the American Heart Association. Circulation. 2013; 129(3):e28-e292. PMC: 5408159. DOI: 10.1161/01.cir.0000441139.02102.80. View

Hao G, Wang X, Treiber F, Harshfield G, Kapuku G, Su S . Blood Pressure Trajectories From Childhood to Young Adulthood Associated With Cardiovascular Risk: Results From the 23-Year Longitudinal Georgia Stress and Heart Study. Hypertension. 2017; 69(3):435-442. PMC: 5300982. DOI: 10.1161/HYPERTENSIONAHA.116.08312. View

Shrivastava S, Shrivastava P, Ramasamy J . Childhood obesity: a determinant of adolescent and adult hypertension. Int J Prev Med. 2014; 5(Suppl 1):S71-2. PMC: 3990923. View

Azegami T, Uchida K, Tokumura M, Mori M . Blood Pressure Tracking From Childhood to Adulthood. Front Pediatr. 2021; 9:785356. PMC: 8634726. DOI: 10.3389/fped.2021.785356. View

10.

Juonala M, Magnussen C, Berenson G, Venn A, Burns T, Sabin M . Childhood adiposity, adult adiposity, and cardiovascular risk factors. N Engl J Med. 2011; 365(20):1876-85. DOI: 10.1056/NEJMoa1010112. View

11.

Kindblom J, Bygdell M, Hjelmgren O, Martikainen J, Rosengren A, Bergstrom G . Pubertal Body Mass Index Change Is Associated With Adult Coronary Atherosclerosis and Acute Coronary Events in Men. Arterioscler Thromb Vasc Biol. 2021; 41(8):2318-2327. PMC: 8288483. DOI: 10.1161/ATVBAHA.121.316265. View

12.

Luijken J, van der Schouw Y, Mensink D, Onland-Moret N . Association between age at menarche and cardiovascular disease: A systematic review on risk and potential mechanisms. Maturitas. 2017; 104:96-116. DOI: 10.1016/j.maturitas.2017.07.009. View

13.

Kwarteng E, Shank L, Faulkner L, Loch L, Fatima S, Gupta S . Influence of puberty on relationships between body composition and blood pressure: a cross-sectional study. Pediatr Res. 2023; 94(2):781-788. PMC: 10403383. DOI: 10.1038/s41390-023-02503-7. View

14.

Goldstein B, Carnethon M, Matthews K, McIntyre R, Miller G, Raghuveer G . Major Depressive Disorder and Bipolar Disorder Predispose Youth to Accelerated Atherosclerosis and Early Cardiovascular Disease: A Scientific Statement From the American Heart Association. Circulation. 2015; 132(10):965-86. DOI: 10.1161/CIR.0000000000000229. View

15.

Nagata J, Garber A, Tabler J, Murray S, Vittinghoff E, Bibbins-Domingo K . Disordered eating behaviors and cardiometabolic risk among young adults with overweight or obesity. Int J Eat Disord. 2018; 51(8):931-941. PMC: 6230303. DOI: 10.1002/eat.22927. View

16.

Zhou J, Rifas-Shiman S, Haines J, Jones K, Oken E . Adolescent overeating and binge eating behavior in relation to subsequent cardiometabolic risk outcomes: a prospective cohort study. J Eat Disord. 2022; 10(1):140. PMC: 9472357. DOI: 10.1186/s40337-022-00660-4. View

17.

Faulconbridge L, Bechtel C . Depression and Disordered Eating in the Obese Person. Curr Obes Rep. 2014; 3(1):127-36. PMC: 3963183. DOI: 10.1007/s13679-013-0080-9. View

18.

Galvao T, Silva M, Zimmermann I, Souza K, Martins S, Pereira M . Pubertal timing in girls and depression: a systematic review. J Affect Disord. 2013; 155:13-9. DOI: 10.1016/j.jad.2013.10.034. View

19.

Ullsperger J, Nikolas M . A meta-analytic review of the association between pubertal timing and psychopathology in adolescence: Are there sex differences in risk?. Psychol Bull. 2017; 143(9):903-938. DOI: 10.1037/bul0000106. View

20.

Bauman V, Sanchez N, Repke H, Spinner H, Thorstad I, Gulley L . Loss of control eating in relation to blood pressure among adolescent girls with elevated anxiety at-risk for excess weight gain. Eat Behav. 2023; 50:101773. DOI: 10.1016/j.eatbeh.2023.101773. View