Breathing Orchestrates Synchronization of Sleep Oscillations in the Human Hippocampus

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2024 Dec 16

PMID 39680758

Authors

Andrew Sheriff

Guangyu Zhou

Vivek Sagar

Justin B Morgenthaler

Christopher Cyr

Katherina K Hauner

Mahmoud Omidbeigi

Joshua M Rosenow

Stephan U Schuele

Gregory Lane

Christina Zelano

Affiliations

Soon will be listed here.

Abstract

Nested sleep oscillations, emerging from asynchronous states in coordinated bursts, are critical for memory consolidation. Whether these bursts emerge intrinsically or from an underlying rhythm is unknown. Here, we show a previously undescribed respiratory-driven oscillation in the human hippocampus that couples with cardinal sleep oscillations. Further, breathing promotes nesting of ripples in slow oscillations, together suggesting that respiration acts as an intrinsic rhythm to coordinate synchronization of sleep oscillations, providing a unique framework to characterize sleep-related respiratory and memory processes.

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