Microstructural Asymmetries of the Planum Temporale Predict Functional Lateralization of Auditory-language Processing

Overview

Journal Elife

Specialty Biology

Date 2024 Dec 16

PMID 39679659

Authors

Peipei Qin

Qiuhui Bi

Zeya Guo

Liyuan Yang

Haokun Li

Peng Li

Xinyu Liang

Junhao Luo

Xiangyu Kong

Yirong Xiong

Bo Sun

Sebastian Ocklenburg

Gaolang Gong

Affiliations

Soon will be listed here.

Abstract

Structural hemispheric asymmetry has long been assumed to guide functional lateralization of the human brain, but empirical evidence for this compelling hypothesis remains scarce. Recently, it has been suggested that microstructural asymmetries may be more relevant to functional lateralization than macrostructural asymmetries. To investigate the link between microstructure and function, we analyzed multimodal MRI data in 907 right-handed participants. We quantified structural asymmetry and functional lateralization of the planum temporale (PT), a cortical area crucial for auditory-language processing. We found associations between PT functional lateralization and several structural asymmetries, such as surface area, intracortical myelin content, neurite density, and neurite orientation dispersion. The PT structure also showed hemispheric-specific coupling with its functional activity. All these functional-structural associations are highly specific to within-PT functional activity during auditory-language processing. These results suggest that structural asymmetry underlies functional lateralization of the same brain area and highlights a critical role of microstructural PT asymmetries in auditory-language processing.

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