Synthesis of Magnetic Luminescent Nanoparticle FeO@LaF:Eu,Ag@APTES@β-CD, a Potential Carrier of Antimicrobial Drug Ciprofloxacin

Overview

Journal Indian J Microbiol

Specialty Microbiology

Date 2024 Dec 16

PMID 39678968

Authors

Sangita Kumari Swain

Ganngam Phaomei

Sandip Kumar Dash

Sukanta Kumar Tripathy

Affiliations

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Abstract

FeO@LaF:Eu,Ag hybrid magnetic luminescent nanoparticles (NPs) were synthesized using a simple co-precipitation method and then functionalized with β-cyclodextrin (β-CD) using (3-aminopropyl)triethoxysilane (APTES). The chemical composition, crystalline nature, particle size, and surface morphology of the FeO@LaF:Eu,Ag@APTES@β-CD NPs were investigated, using powder X-ray diffraction, and high-resolution transmission electron microscopy. The uptake and release profiling of the LaF:Eu,Ag@FeO@β-CD NPs for the hydrophilic drug ciprofloxacin, showed 40 and 85% efficiency, respectively. The results indicated that the NPs have a high drug loading yield and a sustained drug releasing profile of the NPs, indicating that they can be used as a drug carrier. The photoluminescence spectral analysis of the NPs revealed their potentiality for use in bioimaging. Further analysis of the drug-loaded NPs (FeO@LaF:Eu,Ag@APTES@β-CD-ciprofloxacin) revealed, 100% microbial inhibition efficiency against and , and a minimum of 80% against .

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