POU4F1 Enhances Lung Cancer Gemcitabine Resistance by Regulating METTL3-dependent TWF1 MRNA N6 Adenosine Methylation

Overview

Journal 3 Biotech

Publisher Springer

Specialty Biotechnology

Date 2024 Dec 16

PMID 39676891

Authors

Jianfeng Tang

Zhijian Liu

Guanghui Xie

ChenBin Wang

Yongjun Jiang

Affiliations

Soon will be listed here.

Abstract

Supplementary Information: The online version contains supplementary material available at 10.1007/s13205-024-04161-w.

References

Hua Y, Zhu Y, Xie G, Zhang K, Sheng J, Zhu Z . Long non-coding SBF2-AS1 acting as a competing endogenous RNA to sponge microRNA-142-3p to participate in gemcitabine resistance in pancreatic cancer via upregulating TWF1. Aging (Albany NY). 2019; 11(20):8860-8878. PMC: 6834408. DOI: 10.18632/aging.102307. View

Cao W, Gao J, Zhang Y, Li A, Yu P, Cao N . Autophagy up-regulated by MEK/ERK promotes the repair of DNA damage caused by aflatoxin B1. Toxicol Mech Methods. 2021; 32(2):87-96. DOI: 10.1080/15376516.2021.1968985. View

Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S . Autophagy-deficient mice develop multiple liver tumors. Genes Dev. 2011; 25(8):795-800. PMC: 3078705. DOI: 10.1101/gad.2016211. View

Xia H, Green D, Zou W . Autophagy in tumour immunity and therapy. Nat Rev Cancer. 2021; 21(5):281-297. PMC: 8087647. DOI: 10.1038/s41568-021-00344-2. View

Ogura Y, Mizumoto K, Tanaka M, Ohuchida K, Murakami M, Yamada D . Strategy for prevention of local recurrence of pancreatic cancer after pancreatectomy: antitumor effect of gemcitabine mixed with fibrin glue in an orthotopic nude mouse model. Surgery. 2006; 140(1):66-71. DOI: 10.1016/j.surg.2005.11.012. View

Tan X, Zheng C, Zhuang Y, Jin P, Wang F . The m6A reader PRRC2A is essential for meiosis I completion during spermatogenesis. Nat Commun. 2023; 14(1):1636. PMC: 10039029. DOI: 10.1038/s41467-023-37252-y. View

Meyer K . mA-mediated translation regulation. Biochim Biophys Acta Gene Regul Mech. 2018; 1862(3):301-309. PMC: 6401301. DOI: 10.1016/j.bbagrm.2018.10.006. View

Jin D, Guo J, Wu Y, Du J, Yang L, Wang X . mA mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis. J Hematol Oncol. 2021; 14(1):32. PMC: 7901070. DOI: 10.1186/s13045-021-01048-8. View

Debnath J, Gammoh N, Ryan K . Autophagy and autophagy-related pathways in cancer. Nat Rev Mol Cell Biol. 2023; 24(8):560-575. PMC: 9980873. DOI: 10.1038/s41580-023-00585-z. View

10.

Lee Y, Choe J, Park O, Kim Y . Molecular Mechanisms Driving mRNA Degradation by mA Modification. Trends Genet. 2020; 36(3):177-188. DOI: 10.1016/j.tig.2019.12.007. View

11.

Allahyari M, Motavalizadeh-Kakhky A, Mehrzad J, Zhiani R, Chamani J . Cellulose nanocrystals derived from chicory plant: an un-competitive inhibitor of aromatase in breast cancer cells via PI3K/AKT/mTOP signalling pathway. J Biomol Struct Dyn. 2023; 42(11):5575-5589. DOI: 10.1080/07391102.2023.2226751. View

12.

Jiang Z, Yin J, Fu W, Mo Y, Pan Y, Dai L . MiRNA 17 family regulates cisplatin-resistant and metastasis by targeting TGFbetaR2 in NSCLC. PLoS One. 2014; 9(4):e94639. PMC: 3983236. DOI: 10.1371/journal.pone.0094639. View

13.

Fang Z, Mei W, Qu C, Lu J, Shang L, Cao F . Role of m6A writers, erasers and readers in cancer. Exp Hematol Oncol. 2022; 11(1):45. PMC: 9361621. DOI: 10.1186/s40164-022-00298-7. View

14.

Huang Y, Zhen Y, Chen Y, Sui S, Zhang L . Unraveling the interplay between RAS/RAF/MEK/ERK signaling pathway and autophagy in cancer: From molecular mechanisms to targeted therapy. Biochem Pharmacol. 2023; 217:115842. DOI: 10.1016/j.bcp.2023.115842. View

15.

Zhuang H, Yu B, Tao D, Xu X, Xu Y, Wang J . The role of m6A methylation in therapy resistance in cancer. Mol Cancer. 2023; 22(1):91. PMC: 10233906. DOI: 10.1186/s12943-023-01782-2. View

16.

Yu T, Cheng H, Li X, Huang W, Li H, Gao X . Design and synthesis of hederagenin derivatives modulating STING/NF-κB signaling for the relief of acute liver injury in septic mice. Eur J Med Chem. 2022; 245(Pt 1):114911. DOI: 10.1016/j.ejmech.2022.114911. View

17.

Bohlen J, Roiuk M, Neff M, Teleman A . PRRC2 proteins impact translation initiation by promoting leaky scanning. Nucleic Acids Res. 2023; 51(7):3391-3409. PMC: 10123092. DOI: 10.1093/nar/gkad135. View

18.

Dong H, Zeng L, Chen W, Zhang Q, Wang F, Wu Y . N6-methyladenine-mediated aberrant activation of the lncRNA SOX2OT-GLI1 loop promotes non-small-cell lung cancer stemness. Cell Death Discov. 2023; 9(1):149. PMC: 10164154. DOI: 10.1038/s41420-023-01442-w. View

19.

Li J, Xie H, Ying Y, Chen H, Yan H, He L . YTHDF2 mediates the mRNA degradation of the tumor suppressors to induce AKT phosphorylation in N6-methyladenosine-dependent way in prostate cancer. Mol Cancer. 2020; 19(1):152. PMC: 7599101. DOI: 10.1186/s12943-020-01267-6. View

20.

Zhang X, Ye T, Li M, Yan H, Lin H, Lu H . Association of Polymorphisms in Inflammation Genes With the Prognosis of Advanced Non-Small Cell Lung Cancer Patients Receiving Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors. Front Oncol. 2022; 12:836117. PMC: 8971721. DOI: 10.3389/fonc.2022.836117. View