Function of Brain-Derived Neurotrophic Factor in the Vestibular-Cochlear System

Overview

Journal Neurochem Res

Specialties Chemistry
Neurology

Date 2024 Dec 14

PMID 39673652

Authors

Bin Zhang

Su-Lan Chen

Xin Teng

Qi Han

Tong Wu

Zhen Yang

Yin Liu

Ke Xiang

Li Sun

Affiliations

Soon will be listed here.

Abstract

Brain-derived neurotrophic factor (BDNF) is essential for the development and functioning of the vestibular system. BDNF promotes the growth, differentiation, and synaptic plasticity of vestibular neurons, ensuring their normal operation and maintenance. According to research, BDNF is pivotal during vestibular compensation, aiding in the recovery of neuron function by remodeling the spontaneous resting potentials of damaged vestibular neurons. Additionally, BDNF exhibits dose-dependent and age-dependent characteristics during vestibular system development, with its deficiencies leading to the degeneration of vestibular neurons. BDNF dynamically interacts with other neurotrophic factors, such as fibroblast growth factor-2 (FGF-2) and glial cell line-derived neurotrophic factor (GDNF), synergistically enhancing neuron survival and functionality. This review outline the function of BDNF in the vestibulocochlear system and explores its potential therapeutic applications, offering fresh perspectives and guidance for future research and treatment of vestibulocochlear system disorders.

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