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Beyond the Itch: Chronic Kidney Disease-associated Pruritus, a Multimodal Approach, and the Role of Difelikefalin

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Specialty Dermatology
Date 2024 Dec 14
PMID 39673561
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References
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Kimata N, Fuller D, Saito A, Akizawa T, Fukuhara S, Pisoni R . Pruritus in hemodialysis patients: Results from the Japanese Dialysis Outcomes and Practice Patterns Study (JDOPPS). Hemodial Int. 2014; 18(3):657-67. DOI: 10.1111/hdi.12158. View

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Verduzco H, Shirazian S . CKD-Associated Pruritus: New Insights Into Diagnosis, Pathogenesis, and Management. Kidney Int Rep. 2020; 5(9):1387-1402. PMC: 7486142. DOI: 10.1016/j.ekir.2020.04.027. View

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Topf J, Wooldridge T, McCafferty K, Schomig M, Csiky B, Zwiech R . Efficacy of Difelikefalin for the Treatment of Moderate to Severe Pruritus in Hemodialysis Patients: Pooled Analysis of KALM-1 and KALM-2 Phase 3 Studies. Kidney Med. 2022; 4(8):100512. PMC: 9396406. DOI: 10.1016/j.xkme.2022.100512. View

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Stander S, Fishbane S, Schaufler T, Ruessmann D, Morin I, Menzaghi F . Chronic kidney disease-associated pruritus and quality of life with difelikefalin treatment: a analysis of phase 3 data using the Skindex-10 questionnaire. Clin Kidney J. 2024; 17(10):sfae274. PMC: 11484513. DOI: 10.1093/ckj/sfae274. View