» Articles » PMID: 39672895

Emerging Therapeutic Strategies to Mitigate Female and Male Reproductive Aging

Overview
Journal Nat Aging
Specialty Geriatrics
Date 2024 Dec 13
PMID 39672895
Authors
Affiliations
Soon will be listed here.
Abstract

People today are choosing to have children later in life, often in their thirties and forties, when their fertility is in decline. We sought to identify and compile effective methods for improving either male or female fertility in this context of advanced reproductive age. We found few clinical studies with strong evidence for therapeutics that mitigate reproductive aging or extend fertility; however, this Perspective summarizes the range of emerging experimental strategies under development. Preclinical studies, in mouse models of aging, have identified pharmaceutical candidates that improve egg and sperm quality. Further, a diverse array of medically assisted reproduction methodologies, including those that stimulate rare ovarian follicles and rejuvenate egg quality using mitochondria, may have future utility for older patients. Finally, we highlight the many knowledge gaps and possible future directions in the field of therapeutics to extend the age of healthy human reproduction.

References
1.
Fitzpatrick K, Tuffnell D, Kurinczuk J, Knight M . Pregnancy at very advanced maternal age: a UK population-based cohort study. BJOG. 2016; 124(7):1097-1106. PMC: 5484369. DOI: 10.1111/1471-0528.14269. View

2.
Shan D, Qiu P, Wu Y, Chen Q, Li A, Ramadoss S . Pregnancy Outcomes in Women of Advanced Maternal Age: a Retrospective Cohort Study from China. Sci Rep. 2018; 8(1):12239. PMC: 6095911. DOI: 10.1038/s41598-018-29889-3. View

3.
Broekmans F, Soules M, Fauser B . Ovarian aging: mechanisms and clinical consequences. Endocr Rev. 2009; 30(5):465-93. DOI: 10.1210/er.2009-0006. View

4.
Heffner L . Advanced maternal age--how old is too old?. N Engl J Med. 2004; 351(19):1927-9. DOI: 10.1056/NEJMp048087. View

5.
Mathieu C, Ecochard R, Bied V, Lornage J, CZYBA J . Cumulative conception rate following intrauterine artificial insemination with husband's spermatozoa: influence of husband's age. Hum Reprod. 1995; 10(5):1090-7. DOI: 10.1093/oxfordjournals.humrep.a136100. View