Clinical Study of the Effect of Mometasone Furoate Nasal Spray Treatment on Hearing and in Secretory Otitis Media in Children

Overview

Journal Clinics (Sao Paulo)

Publisher Elsevier

Specialty General Medicine

Date 2024 Dec 13

PMID 39671881

Authors

Xiaoyan Yu

Lang Xu

Youqi Xie

Mengjie Huang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the effect of Mometasone furoate (Elocon Cream) Nasal Spray (MFNS) treatment on hearing secretory Otitis Media (SOM) in younger children.

Methods: Seventy-six children with SOM (ages 5 to 10 years-old) were selected as study subjects and divided into two groups of 38 cases each using a randomized numerical table. The control group was given conventional treatment, and the observation group was treated with MFNS based on the control group. Both groups were treated for 12 weeks. The improvements in clinical symptoms and hearing were compared between the two groups at weeks 4, 8 and 12 of treatment, respectively.

Results: The total effective rate of treatment in the observation group was higher than that in the control group. The middle ear resonance frequency of the children in the observation group was higher than that of the control group at weeks 4, 8 and 12 of treatment, and the air-conduction hearing threshold was lower than that of the control group. The total effective rate of the observation group after 12-weeks of treatment was 92.11 %, which was significantly higher than that of the control group (73.68 %). In addition, the T-ETDQ score of the observation group was lower than that of the control group after treatment.

Conclusion: MFNS has clinical efficacy in the treatment of SOM in young children, which can improve clinical symptoms, promote the recovery of hearing and eustachian tube function, reduce the local inflammatory response, and improve immune function.

References

Yin G, Tan J, Li P . Balloon dilation of Eustachian tube combined with tympanostomy tube insertion and middle ear pressure equalization therapy for recurrent secretory otitis media. J Otol. 2019; 14(3):101-105. PMC: 6712345. DOI: 10.1016/j.joto.2019.05.003. View

Cole L, Samii V, Wagner S, Rajala-Schultz P . Diagnosis of primary secretory otitis media in the cavalier King Charles spaniel. Vet Dermatol. 2015; 26(6):459-66, e106-7. DOI: 10.1111/vde.12248. View

Ikeda K, Harashima T, Koike T . Effects of endoscopic sinus surgery on nasal spray deposition using dye-based methods for humans and a human silicone sinonasal cavity model. Am J Otolaryngol. 2021; 42(6):103058. DOI: 10.1016/j.amjoto.2021.103058. View

Nondahl D, Cruickshanks K, Wiley T, Tweed T, Dalton D . Sixteen-year change in acoustic-admittance measures among older adults: data from a population-based study. J Speech Lang Hear Res. 2013; 56(6):1745-50. PMC: 3864143. DOI: 10.1044/1092-4388(2013/12-0381). View

Andresen N, Sharon J, Nieman C, Seal S, Ward B . Predictive value of the Eustachian Tube Dysfunction Questionnaire-7 for identifying obstructive Eustachian tube dysfunction: A systematic review. Laryngoscope Investig Otolaryngol. 2021; 6(4):844-851. PMC: 8356874. DOI: 10.1002/lio2.606. View

Altuntas E, Yener G . Formulation and Evaluation of Thermoreversible In Situ Nasal Gels Containing Mometasone Furoate for Allergic Rhinitis. AAPS PharmSciTech. 2017; 18(7):2673-2682. DOI: 10.1208/s12249-017-0747-8. View

Ahn J, Su Yang J, Jung J, Kang S, Jung S . Association between hearing loss and suicidal ideation: Discrepancy between pure tone audiometry and subjective hearing level. J Affect Disord. 2023; 344:495-502. DOI: 10.1016/j.jad.2023.10.063. View

Birch L, ELBROND O . Presence of interferon in the middle ear during secretory otitis media. Acta Otolaryngol. 1987; 104(5-6):468-71. DOI: 10.3109/00016488709128276. View

Ding Z, Yang N, Cui X, Zhou D . Therapeutic effect of Biyuan tongqiao granules combined with mometasone furoate nasal spray on clinical symptoms of children with allergic rhinitis. Am J Transl Res. 2022; 14(7):5116-5123. PMC: 9360867. View

10.

Skovbjerg S, Roos K, Holm S, Grahn Hakansson E, Nowrouzian F, Ivarsson M . Spray bacteriotherapy decreases middle ear fluid in children with secretory otitis media. Arch Dis Child. 2008; 94(2):92-8. DOI: 10.1136/adc.2008.137414. View

11.

Al-Salim S, Tempero R, Johnson H, Merchant G . Audiologic Profiles of Children With Otitis Media With Effusion. Ear Hear. 2021; 42(5):1195-1207. PMC: 8387329. DOI: 10.1097/AUD.0000000000001038. View

12.

De Corso E, Settimi S, Tricarico L, Mele D, Mastrapasqua R, Di Cesare T . Predictors of Disease Control After Endoscopic Sinus Surgery Plus Long-Term Local Corticosteroids in CRSwNP. Am J Rhinol Allergy. 2020; 35(1):77-85. DOI: 10.1177/1945892420936196. View

13.

Kaufman J, Moglia R, Lacy C, Dinerstein C, Moreyra A . Peripheral vascular complications from percutaneous transluminal coronary angioplasty: a comparison with transfemoral cardiac catheterization. Am J Med Sci. 1989; 297(1):22-5. DOI: 10.1097/00000441-198901000-00006. View

14.

Andrews C, Mohar D, Salhi Y, Tantry S . Efficacy and safety of twice-daily and once-daily olopatadine-mometasone combination nasal spray for seasonal allergic rhinitis. Ann Allergy Asthma Immunol. 2019; 124(2):171-178.e2. DOI: 10.1016/j.anai.2019.11.007. View

15.

Patel P, Salapatek A, Tantry S . Effect of olopatadine-mometasone combination nasal spray on seasonal allergic rhinitis symptoms in an environmental exposure chamber study. Ann Allergy Asthma Immunol. 2018; 122(2):160-166.e1. DOI: 10.1016/j.anai.2018.10.011. View

16.

Ghiselli S, Laborai A, Biasucci G, Carvelli M, Salsi D, Cuda D . Auditory evaluation of infants born to COVID19 positive mothers. Am J Otolaryngol. 2022; 43(2):103379. PMC: 8816906. DOI: 10.1016/j.amjoto.2022.103379. View

17.

Kasiri H, Rouhani N, Salehifar E, Ghazaeian M, Fallah S . Mometasone furoate nasal spray in the treatment of patients with COVID-19 olfactory dysfunction: A randomized, double blind clinical trial. Int Immunopharmacol. 2021; 98:107871. PMC: 8196319. DOI: 10.1016/j.intimp.2021.107871. View

18.

Ras A, Hamed M, Abdelalim A . Montelukast combined with intranasal mometasone furoate versus intranasal mometasone furoate; a comparative study in treatment of adenoid hypertrophy. Am J Otolaryngol. 2020; 41(6):102723. DOI: 10.1016/j.amjoto.2020.102723. View

19.

Kadambott S, Gure P, Ghatak S, Dutta M, Seth C, Das S . How Does Preoperative Pure Tone Audiometry Relate to the Findings at Surgery to Explain the Hearing Status in Chronic Otitis Media?. Medeni Med J. 2023; 38(1):16-23. PMC: 10064100. DOI: 10.4274/MMJ.galenos.2023.30509. View

20.

Nakamura Y, Hamajima Y, Suzuki M, Esaki S, Yokota M, Oshika M . The effect of the leukotriene antagonist pranlukast on pediatric acute otitis media. Int J Pediatr Otorhinolaryngol. 2016; 87:34-8. DOI: 10.1016/j.ijporl.2016.05.027. View