Assessment of Changes in Intra-abdominal Pressure and Cardiac Output Induced by Liver Compression in Healthy Anesthetized Spontaneously Breathing Dogs

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2024 Dec 12

PMID 39666706

Authors

Daeyun Seo

Seongsoo Lim

Beomkwan Namgoong

Heesung Uhm

Hyeajeong Hong

Nanju Lee

Isong Kim

Seunghun Heo

Ji Hwan Kang

Cheyoun Kim

Hayoung Shin

Jiwoong Her

Min Su Kim

Affiliations

Soon will be listed here.

Abstract

Objective: Liver compression (LC) has been proposed to predict fluid responsiveness in human pediatric patients. Because the evaluation of fluid responsiveness through LC depends on the mechanism of increased intra-abdominal pressure (IAP), understanding the impact of LC on IAP, cardiac output (CO), and respiratory parameters is essential. Thus, this study aimed to investigate the effects of LC on these parameters.

Methods: The present study used six healthy beagles. All dogs were anesthetized with isoflurane and allowed to breathe spontaneously in dorsal recumbency. After instrumentation, LC was performed at four different pressures in a sequential, non-randomized manner: (1) 10 mmHg, approximately half of the minimum value within the range; (2) 22 mmHg, a commonly used pressure within the range; (3) 44 mmHg, twice the pressure of the minimum value within the range; and (4) 60 mmHg, twice the pressure of the maximum value within the range. At each pressure, CO via transthoracic echocardiography, IAP, and cardiorespiratory parameters were measured before, during, and after LC.

Results: Overall, our results showed that the IAP was significantly increased at all pressures during LC (P < 0.001), yielding a linear correlation between LC pressure and IAP (P < 0.001; r² = 0.89). The maximum IAP during LC was 7 mmHg, and intra-abdominal hypertension was not induced. LC at 22 mmHg significantly increased the IAP by 1.7 mmHg, but did not significantly alter the CO or respiratory parameters.

Conclusions: This is the first study to evaluate the effects of LC on IAP, CO, and respiratory parameters in healthy, anesthetized, and spontaneously breathing dogs. Our findings indicate that applying LC with a commonly used pressure may have a low risk of inducing intra-abdominal hypertension and related complications. Further studies are required to explore the use of LC in various clinical settings.

References

Fransson B, Grubb T, Perez T, Flores K, Gay J . Cardiorespiratory Changes and Pain Response of Lift Laparoscopy Compared to Capnoperitoneum Laparoscopy in Dogs. Vet Surg. 2014; 44 Suppl 1:7-14. DOI: 10.1111/j.1532-950X.2014.12198.x. View

Vieillard-Baron A, Millington S, Sanfilippo F, Chew M, Diaz-Gomez J, McLean A . A decade of progress in critical care echocardiography: a narrative review. Intensive Care Med. 2019; 45(6):770-788. DOI: 10.1007/s00134-019-05604-2. View

Heck Jr H, Doty D . Assisted circulation by phasic external lower body compression. Circulation. 1981; 64(2 Pt 2):II118-22. View

Kirkpatrick A, Roberts D, De Waele J, Jaeschke R, Malbrain M, De Keulenaer B . Intra-abdominal hypertension and the abdominal compartment syndrome: updated consensus definitions and clinical practice guidelines from the World Society of the Abdominal Compartment Syndrome. Intensive Care Med. 2013; 39(7):1190-206. PMC: 3680657. DOI: 10.1007/s00134-013-2906-z. View

NUNN J . FACTORS INFLUENCING THE ARTERIAL OXYGEN TENSION DURING HALOTHANE ANAESTHESIA WITH SPONTANEOUS RESPIRATION. Br J Anaesth. 1964; 36:327-41. DOI: 10.1093/bja/36.6.327. View

Smith S, Sande A . Measurement of intra-abdominal pressure in dogs and cats. J Vet Emerg Crit Care (San Antonio). 2012; 22(5):530-44. DOI: 10.1111/j.1476-4431.2012.00799.x. View

Kim D, Seo M, Choi G, Lee S, Lee S, Lee W . Cardiovascular and Respiratory Effects of Increased Intra-Abdominal Pressure with and without Dexmedetomidine in Anesthetized Dogs. Vet Sci. 2023; 10(11). PMC: 10675810. DOI: 10.3390/vetsci10110634. View

Lapa K, Mann F, Jackson M, Kerl M . Comparison of right lateral versus left lateral versus sternal recumbence intra-abdominal pressure measurements in normal dogs. J Vet Emerg Crit Care (San Antonio). 2020; 30(3):249-253. DOI: 10.1111/vec.12953. View

Lee J, Jang H, Kang P, Song I, Ji S, Jang Y . Prediction of fluid responsiveness following liver compression in pediatric patients with single ventricle physiology. Paediatr Anaesth. 2022; 32(5):637-646. DOI: 10.1111/pan.14417. View

10.

Wauters J, Wilmer A, Valenza F . Abdomino-thoracic transmission during acs: facts and figures. Acta Clin Belg. 2014; 62 Suppl 1:200-5. DOI: 10.1179/acb.2007.62.s1.026. View

11.

Malbrain M, Chiumello D, Pelosi P, Bihari D, Innes R, Ranieri V . Incidence and prognosis of intraabdominal hypertension in a mixed population of critically ill patients: a multiple-center epidemiological study. Crit Care Med. 2005; 33(2):315-22. DOI: 10.1097/01.ccm.0000153408.09806.1b. View

12.

Garofalo N, Teixeira-Neto F, Rodrigues J, Cerejo S, Aguiar A, Becerra-Velasquez D . Comparison of Transpulmonary Thermodilution and Calibrated Pulse Contour Analysis with Pulmonary Artery Thermodilution Cardiac Output Measurements in Anesthetized Dogs. J Vet Intern Med. 2016; 30(4):941-50. PMC: 5089655. DOI: 10.1111/jvim.13984. View

13.

Conzemius M, Sammarco J, Holt D, Smith G . Clinical determination of preoperative and postoperative intra-abdominal pressures in dogs. Vet Surg. 1995; 24(3):195-201. DOI: 10.1111/j.1532-950x.1995.tb01318.x. View

14.

Kitano Y, Takata M, Sasaki N, Zhang Q, Yamamoto S, Miyasaka K . Influence of increased abdominal pressure on steady-state cardiac performance. J Appl Physiol (1985). 1999; 86(5):1651-6. DOI: 10.1152/jappl.1999.86.5.1651. View

15.

Yi M, Leng Y, Bai Y, Yao G, Zhu X . The evaluation of the effect of body positioning on intra-abdominal pressure measurement and the effect of intra-abdominal pressure at different body positioning on organ function and prognosis in critically ill patients. J Crit Care. 2011; 27(2):222.e1-6. DOI: 10.1016/j.jcrc.2011.08.010. View

16.

Lee J, Song I, Kim E, Kim H, Kim J . Prediction of fluid responsiveness based on liver compression-induced blood pressure changes in children after cardiac surgery. Minerva Anestesiol. 2017; 83(9):939-946. DOI: 10.23736/S0375-9393.17.11544-0. View

17.

Wiese J . The abdominojugular reflux sign. Am J Med. 2000; 109(1):59-61. DOI: 10.1016/s0002-9343(00)00443-5. View

18.

Seo D, Lim S, Namgoong B, Choe A, Uhm H, Hong H . Evaluation of fluid responsiveness using liver compression in dogs with experimentally induced hypovolemia. Am J Vet Res. 2024; 85(10). DOI: 10.2460/ajvr.24.03.0083. View

19.

Jacquet-Lagreze M, Tiberghien N, Evain J, Hanna N, Courtil-Teyssedre S, Lilot M . Diagnostic accuracy of a calibrated abdominal compression to predict fluid responsiveness in children. Br J Anaesth. 2018; 121(6):1323-1331. DOI: 10.1016/j.bja.2018.06.030. View

20.

Mercado P, Maizel J, Beyls C, Titeca-Beauport D, Joris M, Kontar L . Transthoracic echocardiography: an accurate and precise method for estimating cardiac output in the critically ill patient. Crit Care. 2017; 21(1):136. PMC: 5465531. DOI: 10.1186/s13054-017-1737-7. View