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Association Between Particulate Matter Exposure and Chronic Rhinosinusitis

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Journal J Rhinol
Date 2024 Dec 12
PMID 39664877
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Abstract

Chronic rhinosinusitis (CRS) is a relatively common inflammatory disease of the nasal and paranasal sinus mucosa. Several epidemiological studies have established an association between particulate matter (PM) and CRS. Based on those data, PM has emerged as an important environmental factor in the development of CRS. Recent research has investigated the mechanisms and treatment options for CRS caused by PM through cellular experimentation. Therefore, the authors would like to explain the definition of PM, present research investigating the relationship between PM and CRS, and summarize the involved mechanisms reported to date.

References
1.
Lee D, Oh J, Choi H, Kim S, Kim S, Kim B . Eupatilin Inhibits Reactive Oxygen Species Generation via Akt/NF-κB/MAPK Signaling Pathways in Particulate Matter-Exposed Human Bronchial Epithelial Cells. Toxics. 2021; 9(2). PMC: 7922545. DOI: 10.3390/toxics9020038. View

2.
Lee D, Choi H, Oh J, Lee D, Kim S, Kim S . Protective effects of α-lipoic acid on cultured human nasal fibroblasts exposed to urban particulate matter. Int Forum Allergy Rhinol. 2019; 9(6):638-647. DOI: 10.1002/alr.22296. View

3.
Aalapati S, Ganapathy S, Manapuram S, Anumolu G, Prakya B . Toxicity and bio-accumulation of inhaled cerium oxide nanoparticles in CD1 mice. Nanotoxicology. 2013; 8(7):786-98. DOI: 10.3109/17435390.2013.829877. View

4.
Shin C, Byun J, Lee K, Kim B, Noh Y, Tran N . Exosomal miRNA-19a and miRNA-614 Induced by Air Pollutants Promote Proinflammatory M1 Macrophage Polarization via Regulation of RORα Expression in Human Respiratory Mucosal Microenvironment. J Immunol. 2020; 205(11):3179-3190. DOI: 10.4049/jimmunol.2000456. View

5.
Ahmadzada S, Ende J, Alvarado R, Christensen J, Kim J, Rimmer J . Responses of Well-differentiated Human Sinonasal Epithelial Cells to Allergen Exposure and Environmental Pollution in Chronic Rhinosinusitis. Am J Rhinol Allergy. 2019; 33(6):624-633. DOI: 10.1177/1945892419853103. View