Fatty Acid Metabolism Disruptions: A Subtle Yet Critical Factor in Adverse Pregnancy Outcomes

Overview

Journal Int J Biol Sci

Specialty Biology

Date 2024 Dec 12

PMID 39664564

Authors

Xiao-Yan Cao

Meng-Ying Li

Chang-Xiang Shao

Jia-Lu Shi

Tao Zhang

Feng Xie

Ting Peng

Ming-Qing Li

Affiliations

Soon will be listed here.

Abstract

The establishment and maintenance of pregnancy encompass a series of complex and high-energy-consuming physiological processes, resulting in a significant energy demand. Fatty acids, one of the most essential nutrients, play a crucial role in energy supply via oxidation and perform critical biological functions such as anti-inflammatory and anti-oxidant effects, which substantially impact human health. Disordered fatty acid metabolism can cause anomalies in fetal growth and development, as well as a range of pregnancy problems, which can influence the health of both the mother and the fetus. In this review, we innovatively explore the relationship between fatty acid metabolism abnormalities and pregnancy complications, emphasizing the potential of dietary interventions with polyunsaturated fatty acids in improving pregnancy outcomes. These findings provide important evidence for clinical interventions and enhance the understanding and practical application of health management during pregnancy.

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