Genomic Composition and Pathomechanisms of Porcine Circoviruses: A Review

Overview

Journal Virulence

Specialty Microbiology

Date 2024 Dec 11

PMID 39662970

Authors

Yong-Yu Gao

Qian Wang

Han-Wen Li

Shuang Zhang

Jian Zhao

Di Bao

Han Zhao

Kai Wang

Gui-Xue Hu

Feng-Shan Gao

Affiliations

Soon will be listed here.

Abstract

Porcine circovirus (PCV) belongs to the genus within the family ; it has the smallest genome and a complicated classification system comprising PCV1, PCV2, PCV3, and PCV4. Most types of these viruses can cause animals to develop serious diseases; in pigs in particular, it may manifest as postweaning multisystemic wasting syndrome (PMWS), reproductive failure, porcine dermatitis and nephropathy syndrome (PDNS), congenital tremors (CTs), proliferative and necrotizing pneumonia (PNP), lymphoid injury, and immunosuppression. Different types of PCVs cause different types of diseases and sometimes feature no pathogenicity; these various PCV types are associated with different pathomechanisms in animals. In this review, the genomic composition and systemic pathomechanisms of porcine circoviruses are introduced, and future research prospects are discussed.

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References

Nguyen V, Do H, Huynh T, Park Y, Park B, Chung H . Molecular-based detection, genetic characterization and phylogenetic analysis of porcine circovirus 4 from Korean domestic swine farms. Transbound Emerg Dis. 2021; 69(2):538-548. DOI: 10.1111/tbed.14017. View

Karuppannan A, Liu S, Jia Q, Selvaraj M, Kwang J . Porcine circovirus type 2 ORF3 protein competes with p53 in binding to Pirh2 and mediates the deregulation of p53 homeostasis. Virology. 2009; 398(1):1-11. DOI: 10.1016/j.virol.2009.11.028. View

HAMEL A, Lin L, Nayar G . Nucleotide sequence of porcine circovirus associated with postweaning multisystemic wasting syndrome in pigs. J Virol. 1998; 72(6):5262-7. PMC: 110114. DOI: 10.1128/JVI.72.6.5262-5267.1998. View

Sirisereewan C, Thanawongnuwech R, Kedkovid R . Current Understanding of the Pathogenesis of Porcine Circovirus 3. Pathogens. 2022; 11(1). PMC: 8778431. DOI: 10.3390/pathogens11010064. View

Franzo G, Segales J . Porcine circovirus 3 (PCV-3) variability: Is it in the virus or in the classification criteria?. Virol J. 2023; 20(1):26. PMC: 9909946. DOI: 10.1186/s12985-023-01984-6. View

Liu G, Wang Y, Jiang S, Sui M, Wang C, Kang L . Suppression of lymphocyte apoptosis in spleen by CXCL13 after porcine circovirus type 2 infection and regulatory mechanism of CXCL13 expression in pigs. Vet Res. 2019; 50(1):17. PMC: 6394056. DOI: 10.1186/s13567-019-0634-2. View

Niu G, Zhang X, Ji W, Chen S, Li X, Yang L . Porcine circovirus 4 rescued from an infectious clone is replicable and pathogenic in vivo. Transbound Emerg Dis. 2022; 69(5):e1632-e1641. DOI: 10.1111/tbed.14498. View

Khayat R, Brunn N, Speir J, Hardham J, Ankenbauer R, Schneemann A . The 2.3-angstrom structure of porcine circovirus 2. J Virol. 2011; 85(15):7856-62. PMC: 3147897. DOI: 10.1128/JVI.00737-11. View

Victoria J, Wang C, Jones M, Jaing C, McLoughlin K, Gardner S . Viral nucleic acids in live-attenuated vaccines: detection of minority variants and an adventitious virus. J Virol. 2010; 84(12):6033-40. PMC: 2876658. DOI: 10.1128/JVI.02690-09. View

10.

Ellis J, Hassard L, Clark E, Harding J, Allan G, Willson P . Isolation of circovirus from lesions of pigs with postweaning multisystemic wasting syndrome. Can Vet J. 1998; 39(1):44-51. PMC: 1539838. View

11.

Mandrioli L, Sarli G, Panarese S, Baldoni S, Marcato P . Apoptosis and proliferative activity in lymph node reaction in postweaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol. 2004; 97(1-2):25-37. DOI: 10.1016/j.vetimm.2003.08.017. View

12.

Allan G, Krakowka S, Ellis J, Charreyre C . Discovery and evolving history of two genetically related but phenotypically different viruses, porcine circoviruses 1 and 2. Virus Res. 2011; 164(1-2):4-9. DOI: 10.1016/j.virusres.2011.09.013. View

13.

Cui Z, Zhou L, Hu X, Zhao S, Xu P, Li W . Immune Molecules' mRNA Expression in Porcine Alveolar Macrophages Co-Infected with Porcine Reproductive and Respiratory Syndrome Virus and Porcine Circovirus Type 2. Viruses. 2023; 15(3). PMC: 10058123. DOI: 10.3390/v15030777. View

14.

Stadejek T, Wozniak A, Milek D, Biernacka K . First detection of porcine circovirus type 3 on commercial pig farms in Poland. Transbound Emerg Dis. 2017; 64(5):1350-1353. DOI: 10.1111/tbed.12672. View

15.

Larochelle R, Magar R, DAllaire S . Genetic characterization and phylogenetic analysis of porcine circovirus type 2 (PCV2) strains from cases presenting various clinical conditions. Virus Res. 2002; 90(1-2):101-12. DOI: 10.1016/s0168-1702(02)00141-7. View

16.

Li J, Song D, Wang S, Dai Y, Zhou J, Gu J . Antiviral Effect of Epigallocatechin Gallate via Impairing Porcine Circovirus Type 2 Attachment to Host Cell Receptor. Viruses. 2020; 12(2). PMC: 7077276. DOI: 10.3390/v12020176. View

17.

Zhang H, Hu W, Li J, Liu T, Zhou J, Opriessnig T . Novel circovirus species identified in farmed pigs designated as Porcine circovirus 4, Hunan province, China. Transbound Emerg Dis. 2019; 67(3):1057-1061. DOI: 10.1111/tbed.13446. View

18.

Lager K, Gauger P, Vincent A, Opriessnig T, Kehrli Jr M, Cheung A . Mortality in pigs given porcine circovirus type 2 subgroup 1 and 2 viruses derived from DNA clones. Vet Rec. 2007; 161(12):428-9. DOI: 10.1136/vr.161.12.428. View

19.

Wang F, Guo X, Ge X, Wang Z, Chen Y, Cha Z . Genetic variation analysis of Chinese strains of porcine circovirus type 2. Virus Res. 2009; 145(1):151-6. DOI: 10.1016/j.virusres.2009.05.015. View

20.

Ramamoorthy S, Meng X . Porcine circoviruses: a minuscule yet mammoth paradox. Anim Health Res Rev. 2008; 10(1):1-20. DOI: 10.1017/S1466252308001461. View