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Defining Mental Health Conditions Within Primary Care Data: A Validation Study With a Mixed Qualitative and Quantitative Approach

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Date 2024 Dec 11
PMID 39660636
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Abstract

Objectives: To validate codelists for defining a range of mental health (MH) conditions with primary care data, using a mixed qualitative and quantitative approach and without requiring external data.

Methods: We validated Read codelists, selecting and classifying them in three steps. The qualitative step included an in-depth revision of the codes by six doctors. Simultaneously, the quantitative step performed on UK primary care data included an exploratory factor analysis to cluster Read codes in MH conditions to obtain an independent classification. The statistical results informed the qualitative conclusions, generating a final selection and classification.

Results: From a preselected list of 2007 Read codes, a total of 1638 were selected by all doctors. Later, they agreed on classifying these codes into 12 categories of MH disorders. From the same preselected list, a total of 1364 were quantitatively selected. Using data from 497,649 persons who used these Read codes at least once, we performed the exploratory factor analysis, retaining five factors (five categories). Both classifications showed good correspondence, while discrepancies informed decisions on reclassification.

Conclusions: We produced a comprehensive set of medical codes lists for 12 MH conditions validated by a combination of clinical consensus panel and quantitative cluster analysis with cross-validation.

References
1.
Slee A, Nazareth I, Freemantle N, Horsfall L . Trends in generalised anxiety disorders and symptoms in primary care: UK population-based cohort study. Br J Psychiatry. 2020; 218(3):158-164. PMC: 8529638. DOI: 10.1192/bjp.2020.159. View

2.
Rait G, Walters K, Griffin M, Buszewicz M, Petersen I, Nazareth I . Recent trends in the incidence of recorded depression in primary care. Br J Psychiatry. 2009; 195(6):520-4. DOI: 10.1192/bjp.bp.108.058636. View

3.
Pham T, Petersen I, Walters K, Raine R, Manthorpe J, Mukadam N . Trends in dementia diagnosis rates in UK ethnic groups: analysis of UK primary care data. Clin Epidemiol. 2018; 10:949-960. PMC: 6087031. DOI: 10.2147/CLEP.S152647. View

4.
Walters K, Rait G, Griffin M, Buszewicz M, Nazareth I . Recent trends in the incidence of anxiety diagnoses and symptoms in primary care. PLoS One. 2012; 7(8):e41670. PMC: 3411689. DOI: 10.1371/journal.pone.0041670. View

5.
Dave S, Petersen I . Creating medical and drug code lists to identify cases in primary care databases. Pharmacoepidemiol Drug Saf. 2009; 18(8):704-7. DOI: 10.1002/pds.1770. View