The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective

Overview

Journal Clin Cosmet Investig Dermatol

Publisher Dove Medical Press

Specialty Dermatology

Date 2024 Dec 11

PMID 39660030

Authors

Qi Zheng

Yuetong Li

Wenfeng Zhu

Xiang Xu

Guoping Sheng

Lanjuan Li

Affiliations

Soon will be listed here.

Abstract

Background: Previous studies have indicated that human flora may affect the development of scabies, however, no studies have proven a causal relationship between human flora and scabies, which would be detrimental to future in-depth studies on human flora and scabies.

Methods: Mendelian randomization (MR) was used to analyze the causal effect between human microbiota and scabies, with data on intestinal flora and skin flora from two large published studies and data on scabies from the FinnGen database. Five MR analysis methods were used to increase the reliability of the results, and sensitivity analyses were conducted to increase the robustness of the results.

Results: Our results suggest that 13 intestinal flora as well as 7 skin flora can have a causal effect on scabies.

Conclusion: Overall, our results demonstrate a causal relationship between intestinal and skin flora and scabies and are consistent with previous observational findings. This will contribute to the future development of probiotic agents for the prevention or treatment of scabies.

References

Pierezan F, Olivry T, Paps J, Lawhon S, Wu J, Steiner J . The skin microbiome in allergen-induced canine atopic dermatitis. Vet Dermatol. 2016; 27(5):332-e82. DOI: 10.1111/vde.12366. View

Ji X, Wu S, Zhao D, Bai Q, Wang Y, Gong K . Revealing the Impact of Gut Microbiota on Acne Through Mendelian Randomization Analysis. Clin Cosmet Investig Dermatol. 2024; 17:383-393. PMC: 10860601. DOI: 10.2147/CCID.S451104. View

El-Aal A, Hassan M, Gawdat H, Ali M, Barakat M . Immunomodulatory impression of anti and pro-inflammatory cytokines in relation to humoral immunity in human scabies. Int J Immunopathol Pharmacol. 2016; 29(2):188-94. PMC: 5806719. DOI: 10.1177/0394632015627464. View

Yang X, Liu Y, Zhang C, Huang K, Han S, Liang B . An Observational Study: Association Between Atopic Dermatitis and Bacterial Colony of the Skin Based on 16S rRNA Gene Sequencing. Clin Cosmet Investig Dermatol. 2024; 17:1649-1659. PMC: 11268436. DOI: 10.2147/CCID.S464431. View

Larsson S, Butterworth A, Burgess S . Mendelian randomization for cardiovascular diseases: principles and applications. Eur Heart J. 2023; 44(47):4913-4924. PMC: 10719501. DOI: 10.1093/eurheartj/ehad736. View

Mao R, Yu Q, Li J . The causal relationship between gut microbiota and inflammatory dermatoses: a Mendelian randomization study. Front Immunol. 2023; 14:1231848. PMC: 10565349. DOI: 10.3389/fimmu.2023.1231848. View

Ni J, Wu G, Albenberg L, Tomov V . Gut microbiota and IBD: causation or correlation?. Nat Rev Gastroenterol Hepatol. 2017; 14(10):573-584. PMC: 5880536. DOI: 10.1038/nrgastro.2017.88. View

Delanghe L, Spacova I, Van Malderen J, Oerlemans E, Claes I, Lebeer S . The role of lactobacilli in inhibiting skin pathogens. Biochem Soc Trans. 2021; 49(2):617-627. DOI: 10.1042/BST20200329. View

Kanda N, Hoashi T, Saeki H . Nutrition and Atopic Dermatitis. J Nippon Med Sch. 2021; 88(3):171-177. DOI: 10.1272/jnms.JNMS.2021_88-317. View

10.

Gao Q, Liu J, Ma W, Cheng Z, Hao P, Luo N . Genomics-Microbiome Based Assessment of Bidirectional Causality Between Gut Microbiota and Psoriasis. Clin Cosmet Investig Dermatol. 2024; 17:435-445. PMC: 10874884. DOI: 10.2147/CCID.S450227. View

11.

Xie A, Chen A, Chen Y, Luo Z, Jiang S, Chen D . for the treatment and prevention of atopic dermatitis: Clinical and experimental evidence. Front Cell Infect Microbiol. 2023; 13:1137275. PMC: 9978199. DOI: 10.3389/fcimb.2023.1137275. View

12.

Byrd A, Belkaid Y, Segre J . The human skin microbiome. Nat Rev Microbiol. 2018; 16(3):143-155. DOI: 10.1038/nrmicro.2017.157. View

13.

Bergamin G, Hudson J, Currie B, Mounsey K . A systematic review of immunosuppressive risk factors and comorbidities associated with the development of crusted scabies. Int J Infect Dis. 2024; 143:107036. DOI: 10.1016/j.ijid.2024.107036. View

14.

Gan T, Hu J, Liu W, Li C, Xu Q, Wang Y . Causal Association Between Anemia and Cardiovascular Disease: A 2-Sample Bidirectional Mendelian Randomization Study. J Am Heart Assoc. 2023; 12(12):e029689. PMC: 10356041. DOI: 10.1161/JAHA.123.029689. View

15.

Abdul Rahim M, Chilloux J, Martinez-Gili L, Neves A, Myridakis A, Gooderham N . Diet-induced metabolic changes of the human gut microbiome: importance of short-chain fatty acids, methylamines and indoles. Acta Diabetol. 2019; 56(5):493-500. PMC: 6451719. DOI: 10.1007/s00592-019-01312-x. View

16.

Wrzesniewska M, Woloszczak J, Swirkosz G, Szyller H, Gomulka K . The Role of the Microbiota in the Pathogenesis and Treatment of Atopic Dermatitis-A Literature Review. Int J Mol Sci. 2024; 25(12). PMC: 11203945. DOI: 10.3390/ijms25126539. View

17.

Chen Y, Feng S, Li Y, Zhang C, Chao G, Zhang S . Gut microbiota and intestinal immunity-A crosstalk in irritable bowel syndrome. Immunology. 2024; 172(1):1-20. DOI: 10.1111/imm.13749. View

18.

Thomas C, Coates S, Engelman D, Chosidow O, Chang A . Ectoparasites: Scabies. J Am Acad Dermatol. 2019; 82(3):533-548. DOI: 10.1016/j.jaad.2019.05.109. View

19.

Nguyen A, Soulika A . The Dynamics of the Skin's Immune System. Int J Mol Sci. 2019; 20(8). PMC: 6515324. DOI: 10.3390/ijms20081811. View

20.

Mahmud M, Akter S, Tamanna S, Mazumder L, Esti I, Banerjee S . Impact of gut microbiome on skin health: gut-skin axis observed through the lenses of therapeutics and skin diseases. Gut Microbes. 2022; 14(1):2096995. PMC: 9311318. DOI: 10.1080/19490976.2022.2096995. View