Tuning Beneficial Calcineurin Phosphatase Activation to Counter α-synuclein Toxicity in a Yeast Model of Parkinson's Disease

Overview

Journal Neural Regen Res

Date 2024 Dec 10

PMID 39657089

Authors

Srishti Chawla

Mikael Molin

Thomas Nystrom

Affiliations

Soon will be listed here.

References

Creamer T . Calcineurin. Cell Commun Signal. 2020; 18(1):137. PMC: 7456046. DOI: 10.1186/s12964-020-00636-4. View

Stallings N, ONeal M, Hu J, Shen Z, Malter J . Long-term normalization of calcineurin activity in model mice rescues Pin1 and attenuates Alzheimer's phenotypes without blocking peripheral T cell IL-2 response. Alzheimers Res Ther. 2023; 15(1):179. PMC: 10580561. DOI: 10.1186/s13195-023-01323-5. View

Kayatekin C, Amasino A, Gaglia G, Flannick J, Bonner J, Fanning S . Translocon Declogger Ste24 Protects against IAPP Oligomer-Induced Proteotoxicity. Cell. 2018; 173(1):62-73.e9. PMC: 5945206. DOI: 10.1016/j.cell.2018.02.026. View

Domingues R, SantAnna R, da Fonseca A, Robbs B, Foguel D, Outeiro T . Extracellular alpha-synuclein: Sensors, receptors, and responses. Neurobiol Dis. 2022; 168:105696. DOI: 10.1016/j.nbd.2022.105696. View

Chawla S, Ahmadpour D, Schneider K, Kumar N, Fischbach A, Molin M . Calcineurin stimulation by Cnb1p overproduction mitigates protein aggregation and α-synuclein toxicity in a yeast model of synucleinopathy. Cell Commun Signal. 2023; 21(1):220. PMC: 10464345. DOI: 10.1186/s12964-023-01242-w. View

Pflugrad H, Nosel P, Ding X, Schmitz B, Lanfermann H, Barg-Hock H . Brain function and metabolism in patients with long-term tacrolimus therapy after kidney transplantation in comparison to patients after liver transplantation. PLoS One. 2020; 15(3):e0229759. PMC: 7064204. DOI: 10.1371/journal.pone.0229759. View

Scaramuzzino C, Cuoc E, Pla P, Humbert S, Saudou F . Calcineurin and huntingtin form a calcium-sensing machinery that directs neurotrophic signals to the nucleus. Sci Adv. 2022; 8(1):eabj8812. PMC: 8730605. DOI: 10.1126/sciadv.abj8812. View

Zaichick S, Caraveo G . Harnessing IGF-1 and IL-2 as biomarkers for calcineurin activity to tailor optimal FK506 dosage in α-synucleinopathies. Front Mol Biosci. 2023; 10:1292555. PMC: 10716490. DOI: 10.3389/fmolb.2023.1292555. View

Kitamura M, Hiramatsu N . The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity. Biometals. 2010; 23(5):941-50. DOI: 10.1007/s10534-010-9296-2. View

10.

Krobitsch S, Lindquist S . Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins. Proc Natl Acad Sci U S A. 2000; 97(4):1589-94. PMC: 26479. DOI: 10.1073/pnas.97.4.1589. View

11.

Mackiewicz J, Lisek M, Boczek T . Targeting CaN/NFAT in Alzheimer's brain degeneration. Front Immunol. 2023; 14:1281882. PMC: 10701682. DOI: 10.3389/fimmu.2023.1281882. View

12.

Caraveo G, Auluck P, Whitesell L, Chung C, Baru V, Mosharov E . Calcineurin determines toxic versus beneficial responses to α-synuclein. Proc Natl Acad Sci U S A. 2014; 111(34):E3544-52. PMC: 4151770. DOI: 10.1073/pnas.1413201111. View