Gastrointestinal Quality of Life in Children Born with Gastroschisis

Overview

Journal Pediatr Surg Int

Specialties General Surgery
Pediatrics

Date 2024 Dec 10

PMID 39656298

Authors

Matilda Brautigam

Michaela Dellenmark-Blom

Kate Abrahamsson

Cathrine Gatzinsky

Vladimir Gatzinsky

Affiliations

Soon will be listed here.

Abstract

Purpose: The aim was to determine gastrointestinal (GI)-related QoL in children born with gastroschisis (GS).

Methods: Totally, 58/83 families of children (aged 2-18 years) operated for GS at a tertiary pediatric surgical center accepted participation. Children aged 5-18 and one parent (child aged 2-18) completed the Swedish version of the PedsQL™ gastrointestinal symptoms module, evaluating GI-related QoL with 14 different GI-specific scales, norm values for Hirschsprung's disease (HD), esophageal atresia (EA), and functional constipation (FC) that were used for comparison.

Results: Children with GS had significantly lower parent-reported scores on "Gas and bloating" compared with children with EA (77.0 vs 85.5, p = 0.039). In the child report and in the parent report, scores on several GI scales were like those of children with EA. Parents of children with GS had higher scores for 8/14 scales compared to HD and higher scores for 12/14 scales compared to FC. Clinical GS-specific factors for worse GI-QoL were identified, including "Days in ventilator" and "Days with Silo and Patch".

Conclusions: GS has an impact on GI-related QoL, comparable to that in EA, but not to HD or FC. The GS-specific factors of worse QoL show the importance regarding a GS follow-up program including considering clinical factors.

References

Harris J, Poirier J, Selip D, Pillai S, Shah A, Jackson C . Early Closure of Gastroschisis After Silo Placement Correlates with Earlier Enteral Feeding. J Neonatal Surg. 2015; 4(3):28. PMC: 4518187. View

Bhat V, Moront M, Bhandari V . Gastroschisis: A State-of-the-Art Review. Children (Basel). 2020; 7(12). PMC: 7765881. DOI: 10.3390/children7120302. View

Frybova B, Kokesova A, Zemkova D, Mixa V, Vlk R, Rygl M . Quality of life in patients with gastroschisis is comparable with the general population: A questionnaire survey. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2016; 161(1):75-79. DOI: 10.5507/bp.2016.059. View

Meinds R, van der Steeg A, Sloots C, Witvliet M, de Blaauw I, van Gemert W . Long-term functional outcomes and quality of life in patients with Hirschsprung's disease. Br J Surg. 2019; 106(4):499-507. PMC: 6590339. DOI: 10.1002/bjs.11059. View

Tauriainen A, Sankilampi U, Raitio A, Tauriainen T, Helenius I, Vanamo K . The association of perinatal and clinical factors with outcomes in infants with gastroschisis-a retrospective multicenter study in Finland. Eur J Pediatr. 2021; 180(6):1875-1883. PMC: 7853702. DOI: 10.1007/s00431-021-03964-w. View

Brautigam M, Dellenmark-Blom M, Gatzinsky V, Bergstrom J, Abrahamsson K . Linguistic and content validity of the Swedish version of the PedsQL™ gastrointestinal symptoms scales and symptoms module for paediatric patients. Acta Paediatr. 2021; 110(11):3124-3130. DOI: 10.1111/apa.16066. View

Tosello B, Zahed M, Guimond F, Baumstarck K, Faure A, Michel F . Neurodevelopment and Health-Related Quality of Life in Infants Born with Gastroschisis: A 6-Year Retrospective French Study. Eur J Pediatr Surg. 2016; 27(4):352-360. DOI: 10.1055/s-0036-1597268. View

De Bie F, Swaminathan V, Johnson G, Monos S, Scott Adzick N, Laje P . Long-term core outcomes of patients with simple gastroschisis. J Pediatr Surg. 2020; 56(8):1365-1369. DOI: 10.1016/j.jpedsurg.2020.09.008. View

Carpenter J, Wiebe T, Cass D, Olutoye O, Lee T . Assessing quality of life in pediatric gastroschisis patients using the Pediatric Quality of Life Inventory survey: An institutional study. J Pediatr Surg. 2016; 51(5):726-9. DOI: 10.1016/j.jpedsurg.2016.02.012. View

10.

Collins L, Collis B, Trajanovska M, Khanal R, Hutson J, Teague W . Quality of life outcomes in children with Hirschsprung disease. J Pediatr Surg. 2017; 52(12):2006-2010. DOI: 10.1016/j.jpedsurg.2017.08.043. View

11.

Arnold H, Baxter K, Short H, Travers C, Bhatia A, Durham M . Short-term and family-reported long-term outcomes of simple versus complicated gastroschisis. J Surg Res. 2018; 224:79-88. DOI: 10.1016/j.jss.2017.11.054. View

12.

Snoep M, Heus R, Manten G, Lap C, Snoeker B, Lindeboom M . Gastro-intestinal function and quality of life are favorable in adolescent and adult gastroschisis patients. Early Hum Dev. 2019; 141:104936. DOI: 10.1016/j.earlhumdev.2019.104936. View

13.

Nasr A, Grandpierre V, Sullivan K, Wong C, Benchimol E . Long-term Outcomes of Patients Surgically Treated for Hirschsprung Disease. J Can Assoc Gastroenterol. 2021; 4(5):201-206. PMC: 8489523. DOI: 10.1093/jcag/gwaa026. View

14.

Kamity R, Kapavarapu P, Chandel A . Feeding Problems and Long-Term Outcomes in Preterm Infants-A Systematic Approach to Evaluation and Management. Children (Basel). 2021; 8(12). PMC: 8700416. DOI: 10.3390/children8121158. View

15.

Hijkoop A, Rietman A, Wijnen R, Tibboel D, Cohen-Overbeek T, van Rosmalen J . Gastroschisis at school age: what do parents report?. Eur J Pediatr. 2019; 178(9):1405-1412. PMC: 6694033. DOI: 10.1007/s00431-019-03417-5. View

16.

Varni J, Kay M, Limbers C, Franciosi J, Pohl J . PedsQL gastrointestinal symptoms module item development: qualitative methods. J Pediatr Gastroenterol Nutr. 2011; 54(5):664-71. DOI: 10.1097/MPG.0b013e31823c9b88. View

17.

Brautigam M, Abrahamsson K, Gatzinsky V, Saalman R, Hadi L, Nilsson S . The Swedish PedsQL gastrointestinal symptoms scale and symptoms module showed good psychometric performance. Acta Paediatr. 2024; 113(12):2564-2572. DOI: 10.1111/apa.17371. View

18.

Molik K, Gingalewski C, West K, Rescorla F, Scherer L, Engum S . Gastroschisis: a plea for risk categorization. J Pediatr Surg. 2001; 36(1):51-5. DOI: 10.1053/jpsu.2001.20004. View

19.

Besner A, Ferreira J, Ow N, Gaffar R, Guadagno E, Emil S . Patient-reported outcome measures in pediatric surgery - A systematic review. J Pediatr Surg. 2022; 57(5):798-812. DOI: 10.1016/j.jpedsurg.2021.12.036. View

20.

Grossbauer A, Mnatsakanian A, Costeloe A, Thottam P . The effects of untreated reflux on the incidence of dysphagia, oral aversion, and feeding difficulty in the NICU population. Int J Pediatr Otorhinolaryngol. 2023; 174:111734. DOI: 10.1016/j.ijporl.2023.111734. View