Pro-arrhythmic Potential of Proton-pump Inhibitors

Overview

Journal Nat Rev Cardiol

Specialty Cardiology & Vascular Diseases

Date 2024 Dec 9

PMID 39653788

Authors

Pietro Enea Lazzerini

Riccardo Accioli

Pier Leopoldo Capecchi

Maurizio Acampa

Affiliations

Soon will be listed here.

References

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Lazzerini P, Cartocci A, Qu Y, Saponara S, Furini S, Fusi F . Proton Pump Inhibitors Directly Block hERG-Potassium Channel and Independently Increase the Risk of QTc Prolongation in a Large Cohort of US Veterans. Circ Arrhythm Electrophysiol. 2021; 14(7):e010042. DOI: 10.1161/CIRCEP.121.010042. View

Fan W, Liu H, Shen Y, Hong K . The Association of Proton Pump Inhibitors and QT Interval Prolongation in Critically Ill Patients. Cardiovasc Drugs Ther. 2023; 38(3):517-525. DOI: 10.1007/s10557-023-07425-4. View

Lorberbaum T, Sampson K, Chang J, Iyer V, Woosley R, Kass R . Coupling Data Mining and Laboratory Experiments to Discover Drug Interactions Causing QT Prolongation. J Am Coll Cardiol. 2016; 68(16):1756-1764. PMC: 5082283. DOI: 10.1016/j.jacc.2016.07.761. View

Bai A, Wilkinson A, Almufleh A, Rai M, Razak F, Verma A . Ceftriaxone and the Risk of Ventricular Arrhythmia, Cardiac Arrest, and Death Among Patients Receiving Lansoprazole. JAMA Netw Open. 2023; 6(10):e2339893. PMC: 10603497. DOI: 10.1001/jamanetworkopen.2023.39893. View

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Mitsuboshi S, Imai S, Kizaki H, Hori S . Concomitant use of lansoprazole and ceftriaxone is associated with an increased risk of ventricular arrhythmias and cardiac arrest in a large Japanese hospital database. J Infect. 2024; 89(2):106202. DOI: 10.1016/j.jinf.2024.106202. View