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The Importance of Controlling Terminal Complement Activity and Intravascular Hemolysis in Paroxysmal Nocturnal Hemoglobinuria (PNH)

Overview
Journal Am J Hematol
Specialty Hematology
Date 2024 Dec 9
PMID 39651745
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References
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Risitano A, Frieri C, Marano L, Urciuoli E, Sanseverino A, Nannelli C . Massive hemolysis in paroxysmal nocturnal hemoglobinuria after switching from proximal complement inhibitor to anti-C5 therapy: A lesson not to be forgotten. Am J Hematol. 2024; 100(1):163-167. DOI: 10.1002/ajh.27502. View

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Notaro R, Luzzatto L . Breakthrough Hemolysis in PNH with Proximal or Terminal Complement Inhibition. N Engl J Med. 2022; 387(2):160-166. DOI: 10.1056/NEJMra2201664. View

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Jang J, Kim J, Lim C, Kleinman N, Myren K, Wang A . Impact of Lactate Dehydrogenase and Hemoglobin Levels on Clinical Outcomes in Patients With Paroxysmal Nocturnal Hemoglobinuria: Results From the National Korean PNH Registry. J Korean Med Sci. 2024; 39(8):e81. PMC: 10911938. DOI: 10.3346/jkms.2024.39.e81. View

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Brodsky R, Lee J, Nishimura J, Szer J . Lactate dehydrogenase versus haemoglobin: which one is the better marker in paroxysmal nocturnal haemoglobinuria?. Br J Haematol. 2021; 196(2):264-265. DOI: 10.1111/bjh.17860. View

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Hillmen P, Szer J, Weitz I, Roth A, Hochsmann B, Panse J . Pegcetacoplan versus Eculizumab in Paroxysmal Nocturnal Hemoglobinuria. N Engl J Med. 2021; 384(11):1028-1037. DOI: 10.1056/NEJMoa2029073. View