Differential Exposure to Palatable Food and Its Effects on Binge-like Eating Behavior in Adolescent Rats

Overview

Journal Front Psychol

Date 2024 Dec 6

PMID 39640034

Authors

Maria Elena Chavez-Hernandez

Luis Miguel Rodriguez-Serrano

Daniel Diaz-Urbina

Sinuhe Munoz-Sanchez

Mario Humberto Buenrostro-Jauregui

Rodrigo Erick Escartin-Perez

Affiliations

Soon will be listed here.

Abstract

Introduction: Consumption of palatable food (PF) can lead to chronic overconsumption and obesity. Furthermore, adolescents may be vulnerable to excessively reinforcing foods, which increases the probability of developing overweight and obesity in adulthood. The role of PF availability in binge-like intake among adolescents without caloric needs remains unclear. The present study aimed to evaluate which PF access protocol is the most sensitive to induce increased caloric intake and binge-like eating during adolescence.

Methods: We used 24 male Wistar rats [30 postnatal days (PND)]; standard food and water were provided . Rats were randomly assigned to one of three groups: (a) continuous, daily access to PF; (b) intermittent, 1-day access/1-day no-access; or (c) weekend, 3 days-access/4 days no-access. All groups had 1 h access to PF (chocolate sandwich cookies). Access protocols were maintained for 6 weeks; afterward, rats underwent a 7-day withdrawal period, and were then evaluated on a binge-eating test.

Results: Chronic restricted PF access induces binge-like intake, with intermittent access resulting in the highest binge index. Additionally, caloric intake of PF increases over time during adolescence, with differential effects of intermittent and weekend access.

Conclusion: Chronic restricted access to PF during adolescence induces binge-like intake, with differences depending on PF availability. This can lead to chronic overconsumption under non-homeostatic conditions.

Citing Articles

The Administration of Cannabinoid Receptor 2 Agonist Decreases Binge-like Intake of Palatable Food in Mice.

Rodriguez-Serrano L, Chavez-Hernandez M Int J Mol Sci. 2025; 26(5).

PMID: 40076606 PMC: 11900424. DOI: 10.3390/ijms26051981.

References

Hambly C, Speakman J . Mice that gorged during dietary restriction increased foraging related behaviors and differed in their macronutrient preference when released from restriction. PeerJ. 2015; 3:e1091. PMC: 4493644. DOI: 10.7717/peerj.1091. View

Francke P, Tiedemann L, Menz M, Beck J, Buchel C, Brassen S . Mesolimbic white matter connectivity mediates the preference for sweet food. Sci Rep. 2019; 9(1):4349. PMC: 6416305. DOI: 10.1038/s41598-019-40935-6. View

Woodward O, Gribble F, Reimann F, Lewis J . Gut peptide regulation of food intake - evidence for the modulation of hedonic feeding. J Physiol. 2021; 600(5):1053-1078. DOI: 10.1113/JP280581. View

Rospond B, Szpigiel J, Sadakierska-Chudy A, Filip M . Binge eating in pre-clinical models. Pharmacol Rep. 2015; 67(3):504-12. DOI: 10.1016/j.pharep.2014.11.012. View

Boggiano M, Artiga A, Pritchett C, Chandler-Laney P, Smith M, Eldridge A . High intake of palatable food predicts binge-eating independent of susceptibility to obesity: an animal model of lean vs obese binge-eating and obesity with and without binge-eating. Int J Obes (Lond). 2007; 31(9):1357-67. DOI: 10.1038/sj.ijo.0803614. View

Iemolo A, Valenza M, Tozier L, Knapp C, Kornetsky C, Steardo L . Withdrawal from chronic, intermittent access to a highly palatable food induces depressive-like behavior in compulsive eating rats. Behav Pharmacol. 2012; 23(5-6):593-602. PMC: 3934429. DOI: 10.1097/FBP.0b013e328357697f. View

de Andrade Silva S, da Silva A, Braz G, da Silva Pedroza A, de Lemos M, Sellitti D . Overfeeding during development induces temporally-dependent changes in areas controlling food intake in the brains of male Wistar rats. Life Sci. 2021; 285:119951. DOI: 10.1016/j.lfs.2021.119951. View

Ullah R, Shen Y, Zhou Y, Fu J . Perinatal metabolic inflammation in the hypothalamus impairs the development of homeostatic feeding circuitry. Metabolism. 2023; 147:155677. DOI: 10.1016/j.metabol.2023.155677. View

Mumena W, Alnezari A, Safar H, Alharbi N, Alahmadi R, Qadhi R . Media use, dietary intake, and diet quality of adolescents in Saudi Arabia. Pediatr Res. 2023; 94(2):789-795. PMC: 9903280. DOI: 10.1038/s41390-023-02505-5. View

10.

Berthoud H, Munzberg H, Morrison C . Blaming the Brain for Obesity: Integration of Hedonic and Homeostatic Mechanisms. Gastroenterology. 2017; 152(7):1728-1738. PMC: 5406238. DOI: 10.1053/j.gastro.2016.12.050. View

11.

Das J, Salam R, Thornburg K, Prentice A, Campisi S, Lassi Z . Nutrition in adolescents: physiology, metabolism, and nutritional needs. Ann N Y Acad Sci. 2017; 1393(1):21-33. DOI: 10.1111/nyas.13330. View

12.

Chmurzynska A, Mlodzik-Czyzewska M, Radziejewska A, Wiebe D . Hedonic Hunger Is Associated with Intake of Certain High-Fat Food Types and BMI in 20- to 40-Year-Old Adults. J Nutr. 2021; 151(4):820-825. DOI: 10.1093/jn/nxaa434. View

13.

Espitia-Bautista E, Escobar C . Fat rather than sugar diet leads to binge-type eating, anticipation, effort behavior and activation of the corticolimbic system. Nutr Neurosci. 2019; 24(7):508-519. DOI: 10.1080/1028415X.2019.1651104. View

14.

Amancio-Belmont O, Romano-Lopez A, Ruiz-Contreras A, Mendez-Diaz M, Prospero-Garcia O . From adolescent to elder rats: Motivation for palatable food and cannabinoids receptors. Dev Neurobiol. 2016; 77(8):917-927. DOI: 10.1002/dneu.22472. View

15.

Tenk C, Felfeli T . Sucrose and fat content significantly affects palatable food consumption in adolescent male and female rats. Appetite. 2017; 118:49-59. DOI: 10.1016/j.appet.2017.07.016. View

16.

Rossi M, Stuber G . Overlapping Brain Circuits for Homeostatic and Hedonic Feeding. Cell Metab. 2017; 27(1):42-56. PMC: 5762260. DOI: 10.1016/j.cmet.2017.09.021. View

17.

Munoz-Escobar G, Guerrero-Vargas N, Escobar C . Random access to palatable food stimulates similar addiction-like responses as a fixed schedule, but only a fixed schedule elicits anticipatory activation. Sci Rep. 2019; 9(1):18223. PMC: 6890727. DOI: 10.1038/s41598-019-54540-0. View

18.

Spierling S, Kreisler A, Williams C, Fang S, Pucci S, Kines K . Intermittent, extended access to preferred food leads to escalated food reinforcement and cyclic whole-body metabolism in rats: Sex differences and individual vulnerability. Physiol Behav. 2018; 192:3-16. PMC: 6019212. DOI: 10.1016/j.physbeh.2018.04.001. View

19.

Berland C, Castel J, Terrasi R, Montalban E, Foppen E, Martin C . Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis. Mol Psychiatry. 2022; 27(4):2340-2354. DOI: 10.1038/s41380-021-01428-z. View

20.

Placidi R, Chandler P, Oswald K, Maldonado C, Wauford P, Boggiano M . Stress and hunger alter the anorectic efficacy of fluoxetine in binge-eating rats with a history of caloric restriction. Int J Eat Disord. 2004; 36(3):328-41. DOI: 10.1002/eat.20044. View