Mitophagy in Gynecological Malignancies: Roles, Advances, and Therapeutic Potential

Overview

Journal Cell Death Discov

Date 2024 Dec 5

PMID 39639053

Authors

Jiao Wang

Dandan Wang

Affiliations

Soon will be listed here.

Abstract

Mitophagy is a process in which impaired or dysfunctional mitochondria are selectively eliminated through the autophagy mechanism to maintain mitochondrial quality control and cellular homeostasis. Based on specific target signals, several mitophagy processes have been identified. Defects in mitophagy are associated with various pathological conditions, including neurodegenerative disorders, cardiovascular diseases, metabolic diseases, and cancer. Mitophagy has been shown to play a critical role in the pathogenesis of gynecological malignancies and the development of drug resistance. In this review, we have summarized and discussed the role and recent advances in understanding the therapeutic potential of mitophagy in the development of gynecological malignancies. Therefore, the valuable insights provided in this review may serve as a basis for further studies that contribute to the development of novel treatment strategies and improved patient outcomes.

References

Jiang Y, Wang C, Zhou S . Artificial intelligence-based risk stratification, accurate diagnosis and treatment prediction in gynecologic oncology. Semin Cancer Biol. 2023; 96:82-99. DOI: 10.1016/j.semcancer.2023.09.005. View

Guo J, Yang Z, Yang X, Li T, Liu M, Tang H . miR-346 functions as a pro-survival factor under ER stress by activating mitophagy. Cancer Lett. 2017; 413:69-81. DOI: 10.1016/j.canlet.2017.10.030. View

Yuan Y, Zheng Y, Zhang X, Chen Y, Wu X, Wu J . BNIP3L/NIX-mediated mitophagy protects against ischemic brain injury independent of PARK2. Autophagy. 2017; 13(10):1754-1766. PMC: 5640199. DOI: 10.1080/15548627.2017.1357792. View

Wu X, Zheng Y, Liu M, Li Y, Ma S, Tang W . BNIP3L/NIX degradation leads to mitophagy deficiency in ischemic brains. Autophagy. 2020; 17(8):1934-1946. PMC: 8386707. DOI: 10.1080/15548627.2020.1802089. View

Huot J, Baumfalk D, Resendiz A, Bonetto A, Smuder A, Penna F . Targeting Mitochondria and Oxidative Stress in Cancer- and Chemotherapy-Induced Muscle Wasting. Antioxid Redox Signal. 2022; 38(4-6):352-370. PMC: 10081727. DOI: 10.1089/ars.2022.0149. View

Chandra V, Rai R, Benbrook D . Utility and Mechanism of SHetA2 and Paclitaxel for Treatment of Endometrial Cancer. Cancers (Basel). 2021; 13(10). PMC: 8150795. DOI: 10.3390/cancers13102322. View

Brown J, Esnouf R, Jones M, Linnell J, Harlos K, Hassan A . Structure of a functional IGF2R fragment determined from the anomalous scattering of sulfur. EMBO J. 2002; 21(5):1054-62. PMC: 125895. DOI: 10.1093/emboj/21.5.1054. View

Bokhman J . Two pathogenetic types of endometrial carcinoma. Gynecol Oncol. 1983; 15(1):10-7. DOI: 10.1016/0090-8258(83)90111-7. View

Putral L, Bywater M, Gu W, Saunders N, Gabrielli B, Leggatt G . RNA interference against human papillomavirus oncogenes in cervical cancer cells results in increased sensitivity to cisplatin. Mol Pharmacol. 2005; 68(5):1311-9. DOI: 10.1124/mol.105.014191. View

10.

Wang J, Xu Z, Hu X, Yang Y, Su J, Liu Y . Epoxycytochalasin H: An Endophytic Compound Induces Apoptosis in A2780 Cells Through Mitochondrial Damage and Endoplasmic Reticulum Stress. Onco Targets Ther. 2020; 13:4987-4997. PMC: 7280062. DOI: 10.2147/OTT.S253716. View

11.

Liu Y, Lu S, Wu L, Yang L, Yang L, Wang J . The diversified role of mitochondria in ferroptosis in cancer. Cell Death Dis. 2023; 14(8):519. PMC: 10425449. DOI: 10.1038/s41419-023-06045-y. View

12.

Wang X, Ling G, Wei Y, Li W, Zhang Y, Tan N . Activation of ULK1 to trigger FUNDC1-mediated mitophagy in heart failure: Effect of Ginsenoside Rg3 intervention. Phytomedicine. 2023; 120:155042. DOI: 10.1016/j.phymed.2023.155042. View

13.

Vianello C, Cocetta V, Catanzaro D, Dorn 2nd G, De Milito A, Rizzolio F . Cisplatin resistance can be curtailed by blunting Bnip3-mediated mitochondrial autophagy. Cell Death Dis. 2022; 13(4):398. PMC: 9033831. DOI: 10.1038/s41419-022-04741-9. View

14.

Meng Y, Qiu L, Zeng X, Hu X, Zhang Y, Wan X . Targeting CRL4 suppresses chemoresistant ovarian cancer growth by inducing mitophagy. Signal Transduct Target Ther. 2022; 7(1):388. PMC: 9731993. DOI: 10.1038/s41392-022-01253-y. View

15.

Praharaj P, Naik P, Panigrahi D, Bhol C, Mahapatra K, Patra S . Intricate role of mitochondrial lipid in mitophagy and mitochondrial apoptosis: its implication in cancer therapeutics. Cell Mol Life Sci. 2018; 76(9):1641-1652. PMC: 11105358. DOI: 10.1007/s00018-018-2990-x. View

16.

DArcy M . Mitophagy in health and disease. Molecular mechanisms, regulatory pathways, and therapeutic implications. Apoptosis. 2024; 29(9-10):1415-1428. DOI: 10.1007/s10495-024-01977-y. View

17.

Johansen T, Lamark T . Selective Autophagy: ATG8 Family Proteins, LIR Motifs and Cargo Receptors. J Mol Biol. 2019; 432(1):80-103. DOI: 10.1016/j.jmb.2019.07.016. View

18.

Jee S, Cheong H . Autophagy/Mitophagy Regulated by Ubiquitination: A Promising Pathway in Cancer Therapeutics. Cancers (Basel). 2023; 15(4). PMC: 9954143. DOI: 10.3390/cancers15041112. View

19.

Ma F, Li H, Huo H, Han Q, Liao J, Zhang H . N-acetyl-L-cysteine alleviates FUNDC1-mediated mitophagy by regulating mitochondrial dynamics in type 1 diabetic nephropathy canine. Life Sci. 2022; 313:121278. DOI: 10.1016/j.lfs.2022.121278. View

20.

Gong X, Pu X, Wang J, Yang L, Cui Y, Li L . Enhancing of Nanocatalyst-Driven Chemodynaminc Therapy for Endometrial Cancer Cells Through Inhibition of PINK1/Parkin-Mediated Mitophagy. Int J Nanomedicine. 2021; 16:6661-6679. PMC: 8487866. DOI: 10.2147/IJN.S329341. View