Manganese-functionalized MXene Theranostic Nanoplatform for MRI-guided Synergetic Photothermal/chemodynamic Therapy of Cancer

Overview

Journal Nanophotonics

Publisher De Gruyter

Date 2024 Dec 5

PMID 39634295

Authors

Dong An

Xin Wu

Yaolin Gong

Wenlu Li

Guidong Dai

Xiaofei Lu

Liangmin Yu

Wen Xiu Ren

Meng Qiu

Jian Shu

Affiliations

Soon will be listed here.

Abstract

Two-dimensional transition metal carbides and nitrides (MXenes) nanosheets with high photothermal conversion efficiency as well as photothermal stability can efficiently generate remarkable hyperthermia for photothermal therapy (PTT) of cancer. However, mono-MXenes cannot exhibit precise diagnosis and treatment to complete ablation of cancer cells in the PTT process. To overcome this dilemma, an "all-in-one" nanoplatform of titanium carbide (TiC) MXene-based composite nanosheets is developed for magnetic resonance imaging (MRI)-guided multi-modal hyperthermia and chemodynamic tumor ablation, which was achieved by bonding of manganese ion on the surface of TiC, and then was the functionalized nanosheets was modified by biocompatible PEG (Mn-TiC@PEG). Due to magnetic and Fenton-like catalytic properties of Mn components, Mn-TiC@PEG not only acted as the contrast agents for T-weighted MRI (relaxivity value of 1.05 mM s), but also converted cellular HO into highly toxic hydroxyl radicals (·OH) mediated chemodynamic therapy (CDT). Moreover, Furthermore, Mn-TiC@PEG can efficiently suppressed tumor-growth by PTT, due to the high photothermal conversion capability and photothermal stability. As a proof-of-concept model, the as-designed Mn-TiC@PEG nanoplatform shows simultaneous MRI and dual-modal treatment for effective suppression of tumor with minimized side effects both and , indicating the great potential for clinical cancer theranostics.

Citing Articles

Manganese-based nanomaterials in diagnostics and chemodynamic therapy of cancers: new development.

Wu M, Liao Y, Guo D, Zhai M, Xia D, Zhang Z RSC Adv. 2024; 14(21):14722-14741.

PMID: 38716093 PMC: 11074770. DOI: 10.1039/d4ra01655f.

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