High Level of Systemic Immune Inflammation Index Elevates Delirium Risk Among Patients in Intensive Care Unit

Overview

Journal Sci Rep

Specialty Science

Date 2024 Dec 5

PMID 39632969

Authors

Feifei Xu

Shurong Zhang

Yanyuan Zhang

Affiliations

Soon will be listed here.

Abstract

Methods: Information was extracted from Medical Information Mart for Intensive Care-IV. Four logistic regression model was established and incorporated with subgroup analysis and restricted cubic spline (RCS). The cutoff value of SII was acquired from receiver operator characteristic curve (ROC), and propensity score matching (PSM) was utilized to attenuate the confounding effect. Survival analysis was utilized to evaluate the relationship between SII and 30-day or 90-day all-cause mortality.

Results: Among the 7,518 participants, 1,685 cases of delirium occurred. Individuals in the highest quartile of SII exhibited a heightened delirium risk, with a significant multivariable-adjusted odds ratio (OR) of 3.12(2.24,4.33). Tendency analysis, subgroup analysis and PSM together confirmed the positive relationship. Results of Cox regression displayed the risk of both 30-day and 90-day mortality increased about 50% in the higher-SII group.

Conclusion: Higher levels of SII is positively associated with the occurrence of delirium and increased all-cause mortality risk.

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