[Role of Mitochondria in Ferroptosis and Its Relationship to Tumors]

Overview

Journal Zhongguo Fei Ai Za Zhi

Specialties Oncology
Pulmonary Medicine

Date 2024 Dec 4

PMID 39631835

Authors

Zhanrui Zhang

Hongyu Liu

Jun Chen

Affiliations

Soon will be listed here.

Abstract

Ferroptosis is a recently discovered form of cell death that is distinct from apoptosis, characterized primarily by the accumulation of intracellular iron and increased levels of lipid peroxidation. Resistance of tumor cells to ferroptosis can promote tumorigenesis and tumor progression. Various compounds can influence tumor development by triggering ferroptosis. Ferroptosis involves complex regulatory mechanisms, with mitochondria serving as both an iron storage and metabolic center, playing a crucial regulatory role in ferroptosis. This review discusses ferroptosis and its three stages and the role of ferroptosis in tumorigenesis, progression, and treatment, as well as the regulatory mechanisms of mitochondria in ferroptosis. .

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