Sustainable and Solvent-free Synthesis of Molecules of Pharmaceutical Importance by Ball Milling

The solvent-free mechanochemical reactions under ball milling have emerged as a promising alternative to traditional solution-based chemistry. This approach not only eliminates the necessity for large quantities of solvents and minimizes waste production, but it also facilitates a unique reaction environment that enables strategies, reactions, and compound syntheses that are typically unattainable in solution. This solvent-less synthetic strategy under ball-milling has been well employed in synthetic organic chemistry in accessing various potential organic molecules including pharmaceutically important molecules and pharmaceuticals or drug-molecules. This review highlights the potential of ball milling in the synthesis of pharmaceutically important classes of molecules without using any solvent (solvent-free conditions).