Combination Therapy of Albendazole and Praziquantel for Treatment of Cardiac and Multiorgan Hydatid Cyst: A Case Report of Novel Treatment and Literature Review

Overview

Journal Clin Case Rep

Date 2024 Dec 2

PMID 39619313

Authors

Soroush Najdaghi

Azin Alizadehasl

Narguess Abbaszade

Seyedeh Fatemeh Hosseini Jebelli

Delaram Narimani Davani

Azam Yalameh Aliabadi

Mehrdad Haghazali

Alireza Yaghoubi Gloverdi

Affiliations

Soon will be listed here.

Abstract

Cardiac hydatid cysts (CHC) are rare complications of echinococcosis, often presenting diagnostic and therapeutic challenges. We report a case of recurrent CHC in a 35-year-old male with a history of cerebral and pelvic hydatid cysts. Diagnostic imaging revealed significant cardiac involvement, necessitating surgical intervention. Postoperative management included a combination of albendazole and praziquantel, resulting in marked improvement during follow-up. This case highlights the complexities of treating recurrent CHC and suggests that combination therapy may offer benefits in managing extensive cysts. Further research is needed to refine treatment strategies for such cases.

References

Cakir O, Sade R, Alper F . Radiological imaging of pericardial hydatid cyst. Rev Soc Bras Med Trop. 2021; 54. PMC: 8008908. DOI: 10.1590/0037-8682-0753-2020. View

Popova G, Vuchev D, Anichina K . Treatment of hepatic and pulmonary hydatidosis with albendazole and praziquantel. Helminthologia. 2023; 60(3):221-226. PMC: 10750241. DOI: 10.2478/helm-2023-0028. View

Alshoabi S, Alkalady A, Almas K, Magram A, Algaberi A, Alareqi A . Hydatid Disease: A Radiological Pictorial Review of a Great Neoplasms Mimicker. Diagnostics (Basel). 2023; 13(6). PMC: 10047450. DOI: 10.3390/diagnostics13061127. View

Kantzanou M, Karalexi M, Vassalos C, Kostare G, Vrioni G, Tsakris A . Central nervous system cystic echinococcosis: a systematic review. Germs. 2022; 12(2):283-291. PMC: 9719387. DOI: 10.18683/germs.2022.1330. View

Noaman H, Rawaf S, Majeed A, Salmasi A . Hydatid Cyst of the Heart. Angiology. 2017; 68(9):765-768. DOI: 10.1177/0003319717690093. View

Vrints C . Focus on cardiac arrhythmias and conduction disorders. Eur Heart J Acute Cardiovasc Care. 2019; 8(2):101-103. DOI: 10.1177/2048872619839639. View

Mohamed A, Yasawy M, Al Karawi M . Combined albendazole and praziquantel versus albendazole alone in the treatment of hydatid disease. Hepatogastroenterology. 1998; 45(23):1690-4. View

Alvela-Suarez L, Velasco-Tirado V, Belhassen-Garcia M, Novo-Veleiro I, Pardo-Lledias J, Romero-Alegria A . Safety of the combined use of praziquantel and albendazole in the treatment of human hydatid disease. Am J Trop Med Hyg. 2014; 90(5):819-22. PMC: 4015571. DOI: 10.4269/ajtmh.13-0059. View

Moraes R, Brida M, Reis R, Silva R, de Farias C . Cardiac Hydatid Cyst: An Uncommon Cause of Complete Atrioventricular Block. Arq Bras Cardiol. 2023; 120(5):e20220597. PMC: 10348382. DOI: 10.36660/abc.20220597. View

10.

Jamshidi M, Mohraz M, Zangeneh M, Jamshidi A . The effect of combination therapy with albendazole and praziquantel on hydatid cyst treatment. Parasitol Res. 2008; 103(1):195-9. DOI: 10.1007/s00436-008-0954-z. View

11.

Cancelo M, Martin M, Mendoza N . Preoperative diagnosis of a breast hydatid cyst using fine-needle aspiration cytology: a case report and review of the literature. J Med Case Rep. 2012; 6:293. PMC: 3485117. DOI: 10.1186/1752-1947-6-293. View

12.

Haralabidis S, Diakou A, Frydas S, Papadopoulos E, Mylonas A, Patsias A . Long-term evaluation of patients with hydatidosis treated with albendazole and praziquantel. Int J Immunopathol Pharmacol. 2008; 21(2):429-35. DOI: 10.1177/039463200802100223. View

13.

Banisefid E, Baghernezhad K, Beheshti R, Hamzehzadeh S, Nemati S, Samadifar Z . Cardiac hydatid disease; a systematic review. BMC Infect Dis. 2023; 23(1):600. PMC: 10500901. DOI: 10.1186/s12879-023-08576-3. View

14.

Bajdechi M, Manolache D, Tudor A, Orghidan M, Gurghean A . Cardiac hydatid cysts in a young man: A case report and a literature review. Exp Ther Med. 2022; 24(3):550. PMC: 9366287. DOI: 10.3892/etm.2022.11487. View

15.

Fennira S, Kamoun S, Besbes B, Ben Mrad I, Zairi I, Ben Moussa F . Cardiac hydatid cyst in the interventricular septum: A literature review. Int J Infect Dis. 2019; 88:120-126. DOI: 10.1016/j.ijid.2019.09.004. View

16.

Ozbudak E, Durmaz D, Arikan A, Halici U, Yavuz S, Emre E . Incidentally detected cardiac cyst hydatid after blunt thoracic trauma. Korean J Thorac Cardiovasc Surg. 2014; 47(2):160-2. PMC: 4000877. DOI: 10.5090/kjtcs.2014.47.2.160. View

17.

Jamli M, Cherif T, Ajmi N, Besbes T, Mgarrech I, Jerbi S . Surgical Management and Outcomes of Cardiac and Great Vessels Echinococcosis: A 16-Year Experience. Ann Thorac Surg. 2020; 110(4):1333-1338. DOI: 10.1016/j.athoracsur.2020.01.065. View

18.

Moro P, Schantz P . Echinococcosis: a review. Int J Infect Dis. 2008; 13(2):125-33. DOI: 10.1016/j.ijid.2008.03.037. View

19.

Yasawy M, Al Karawi M, Mohamed A . Combination of praziquantel and albendazole in the treatment of hydatid disease. Trop Med Parasitol. 1993; 44(3):192-4. View

20.

Prasad K, Kumar R, Halder V, Raju M, Negi S, Naganur S . Multimodality imaging of an interventricular septum hydatid cyst. Egypt Heart J. 2021; 73(1):23. PMC: 7943659. DOI: 10.1186/s43044-021-00147-8. View